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The Role Of Antibody In Inflammatory Demyelinating Neuropathy
Funder
National Health and Medical Research Council
Funding Amount
$218,566.00
Summary
The causes and disease mechanism of inflammatory neuropathy remain unknown. Although treatments have been developed (intravenous immunoglobulin and plasma exchange) they are extremely expensive and non specific in action and beyond the means of the worlds most populous nations. These studies plan to illuminate the mechanism of disease production so that better and more affordable therapy can be developed. We have shown that antibodies which cause nerve damage are present in patients serum. Antib ....The causes and disease mechanism of inflammatory neuropathy remain unknown. Although treatments have been developed (intravenous immunoglobulin and plasma exchange) they are extremely expensive and non specific in action and beyond the means of the worlds most populous nations. These studies plan to illuminate the mechanism of disease production so that better and more affordable therapy can be developed. We have shown that antibodies which cause nerve damage are present in patients serum. Antibodies bind to specific target molecules and our work is close to identifying that target on nerve. We also plan to study how antibody leaks into nerve. This knowledge should allow more specific and effective treatment to be developed.Read moreRead less
Development Of A New Method Of Motor Unit Number Estimation For Use In Motor Neurone Disease
Funder
National Health and Medical Research Council
Funding Amount
$480,127.00
Summary
This project aims to help understand motor neurone disease, which is a severe disease that leads to paralysis and death. In motor neurone disease there is of death of the nerve cells that maks muscles move. We have developed a new method of measuring the number of motor nerve cells. We will use this to study the different types of motor neurone disease.
Flecainide In Amyotrophic Lateral Sclerosis - A Neuroprotective Strategy
Funder
National Health and Medical Research Council
Funding Amount
$593,275.00
Summary
This project will provide clinical trial information related to the potential neuroprotective properties of flecainide in motor neurone disease patients. A potential therapeutic response would provide impetus for a larger scale, multi-centre clinical trial. In addition to providing information about potential mechanisms of neurodegeneration and their treatment, new quantifiable measures will be further developed to objectively monitor MND patients in a clinical trials setting.
Postsynaptic Signalling Systems That Sustain The Nerve-muscle Synapse
Funder
National Health and Medical Research Council
Funding Amount
$598,041.00
Summary
Neuromuscular junctions (NMJ) are the synapses through which motor nerves control our voluntary muscle cells. This project will investigate the molecular signalling system between nerve and muscle that helps maintain healthy NMJs. Normal ageing involves a progressive decline in muscle strength, often leading to loss of independence in the elderly. We will use a mouse model to test whether a breakdown of the NMJ signalling system contributes to the loss of strength in old age.