Increasing Global Equity In Access To End-stage Kidney Disease Care Through Better Peritoneal Dialysis Affordability, Practice, Quality And Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$2,511,960.00
Summary
Kidney disease is a growing problem worldwide and places an enormous burden on patients and their families. People with kidney disease are more likely to die, get cancer, have heart problems and have poor mental and emotional health than the general population. This program of research aims to consult widely with patients and their families and build on previous research knowledge to bring better evidence for therapies to improve the lives of people living with kidney disease.
Signalling Pathways In Antibody-Mediated Renal Injury
Funder
National Health and Medical Research Council
Funding Amount
$113,296.00
Summary
Many types of kidney disease are induced by antibody binding to the kidney which initiates a damaging response by cells of the immune system. Current therapies for such diseases rely upon toxic immunosuppressive drugs. This project will examine one specific mechanism by which immune cells are activated by antibody to cause injury in human and experimental renal injury. These studies will determine whether this specific mechanism is a suitable target for developing new therapeutic drugs.
Supporting The Pathways To Palliative Care For People Diagnosed With Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$43,575.00
Summary
Palliative care is highly relevant to the care of people with chronic kidney disease (CKD). As the person’s kidneys fail, dialysis or transplant will be required to prolong life. Palliative care is another option should patients choose not to have treatment. The health care team plays an important role in offering and supporting this choice but the planned patient care pathway often does not include palliative care as an option until the patient’s prognosis is very poor. Health professionals’ ow ....Palliative care is highly relevant to the care of people with chronic kidney disease (CKD). As the person’s kidneys fail, dialysis or transplant will be required to prolong life. Palliative care is another option should patients choose not to have treatment. The health care team plays an important role in offering and supporting this choice but the planned patient care pathway often does not include palliative care as an option until the patient’s prognosis is very poor. Health professionals’ own beliefs, values and knowledge about palliative care, death and dying, impact upon their decision to offer and support a palliative care option. This research which will be conducted in Northern Tasmania and will explore how palliative care is currently integrated into the care of patients with CKD and the perceptions that health professionals have about palliative care that may influence their decision making. From this information the research team and participating staff will develop the foundational protocols, resources and education and support program needed to introduce a multidisciplinary care pathway that integrates palliative care for all CKD patients.Read moreRead less
A Life Course Approach To Improving The Health And Well-being Of Young People With Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$193,360.00
Summary
Children with kidney disease suffers from profound ill-health and adopt a restrictive lifestyle, including dietary restriction, absences from school and other co-curricular activities. New knowledge and interventions are needed to address the pressing needs including of these children and their caregivers. This program of work will adopt a life-course approach to determine the protective and risk factors that affect the overall health and well-being of children with chronic kidney disease.
Standardised Outcomes In Nephrology – Peritoneal Dialysis (SONG-PD): Establishing A Core Outcome Set In Peritoneal Dialysis
Funder
National Health and Medical Research Council
Funding Amount
$66,502.00
Summary
Standardised Outcomes in Nephrology-Peritoneal Dialysis study aims to establish a set of core outcomes for trials in PD based on the shared priorities of all stakeholders, so that outcomes of most relevance for decision making can be evaluated, and that interventions can be compared reliably.
Spleen Tyrosine Kinase (Syk) As A Therapeutic Target In Antibody-dependent Transplant Rejection.
Funder
National Health and Medical Research Council
Funding Amount
$625,919.00
Summary
While kidney transplantation is a life saving treatment for those with end-stage kidney failure, a significant number of patients face long waits on dialysis because they have antibodies that would cause rejection of most potential donor kidneys. This project seeks to address this problem using a new strategy to treat antibody-mediated rejection and thereby enable such patients to receive a transplant without the fear of severe rejection.
20% of transplanted kidneys undergo rejection. This can permanently damage or destroy the transplant. Presently, rejection is identified when the kidney function deteriorates. This can occur late after rejection has started. To confirm the diagnosis of rejection, an invasive biopsy associated with discomfort and risks is required. This study will evaluate the use of a simpler blood test to monitor for rejection, allowing earlier and safer identification and treatment.