Multifunctional Regualtion Of Angiogenesis By High Density Lipoproteins
Funder
National Health and Medical Research Council
Funding Amount
$480,653.00
Summary
For many sufferers of heart disease and cancer, current treatments do not relieve the debilitating symptoms. The growth of new blood vessels can alleviate the effects of a restricted blood supply, caused by blocked arteries. Conversely, new vessel growth accelerates some diseases such as cancer. HDL is one of the main forms of cholesterol in the blood. Recently we identified a beneficial bifunctional role for HDL in vessel growth. This project will investigate the mechanisms for these effects.
Beta-Adrenergic Activation: A Double-edged Sword On Cardiac Angiogenesis
Funder
National Health and Medical Research Council
Funding Amount
$365,126.00
Summary
We will test our hypothesis that activation of beta-adrenergic receptors (b-AR) regulates significantly on growth of blood vessels in the heart. While initialy promoting vessel growth, prolonged stimulation of b-AR, a situation seen with diseased hearts, suppresses vessel growth thereby promoting disease progression. This hypothesis is strongly supported by our recent experimental findings and would have important clinical implication on the treatment of patients with heart disease.