Identification Of Novel Regulators Of Flt3 Receptor-dependent Dendritic Cell Development And Differentiation
Funder
National Health and Medical Research Council
Funding Amount
$605,043.00
Summary
Dendritic cells are specialized immune cells that play a key role in regulating the immune system. In the resting animal, their differentiation is largely regulated by signalling though the Flt3 pathway - the pathway most frequently dysregulated in leukemias. This project will generate a a detailed map of the important signals that instruct dendritic cell development along the Flt3 pathway and provide improved understanding of the cellular and molecular controls of this pathway.
Mast Cells Are Key Negative Regulators Of Skin Tumourigenesis
Funder
National Health and Medical Research Council
Funding Amount
$687,519.00
Summary
Australians are at high risk of sun-induced skin cancer and skin damage caused by the harmful ultraviolet (UV)-B rays in sunlight. Our research focuses on understanding how skin mast cells act as part of the body’s natural defence against skin tumourigenesis caused by excessive UVB exposure or chemical insult to the epidermis. Understanding the innate mechanisms that protect against excessive skin damage and cancer might lead to better prevention and treatment strategies in the future.