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The Glyco-interactome Of Pathogenic Neisseria: Understanding Disease And Defining Vaccine Targets
Funder
National Health and Medical Research Council
Funding Amount
$431,012.00
Summary
In order to infect humans and cause disease, many bacteria rely on interactions with carbohydrate (sugar) structures on human cells. This project aims to characterise the sugar interactions that enable Neisseria meningitidis (causes meningitis, sepsis) and Neisseria gonorrhoeae (causes gonorrhoea, associated with infertility and increased transmission of HIV) to cause disease. This will increase our understanding of host-pathogen interactions and aid development of new vaccines and therapeutics.
Identification Of Novel Gonococcal Virulence Factors And Vaccine Antigens Based On Their Expression During Host Cell Contact And Their Role In Association, Invasion And Survival In Cervical Epithelia
Funder
National Health and Medical Research Council
Funding Amount
$371,922.00
Summary
The sexually transmitted infection gonorrhoea is a significant health problem worldwide. Control of gonorrhoea depends on the development of a vaccine due to the continuing increase of antibiotic resistance and the staggering outcomes of infection, including infertility and increased transmission of HIV. My research aims to discover new vaccine targets by identifying gonococcal proteins that are required for interaction with human cervical cells.
Structure-based Design Of Novel Therapeutics For Multi-drug Resistant Neisseria Gonorrhoeae
Funder
National Health and Medical Research Council
Funding Amount
$669,148.00
Summary
Multiple drug resistance (MDR) in bacteria represents one of the most intractable problems facing modern medicine. The recent superbug, MDR-Neisseria gonorrhoeae (MDR-Ng), causes the sexually transmitted infection gonorrhoeae. A multi disciplinary team with expertise in structural biology, medicinal chemistry and bacteriology will establish a comprehensive knowledge base aimed at developing new antibiotics to treat MDR-Ng by targeting a bacterial protein virulence factor.
The Role Of Lipooligosaccharide Phosphoethanolamine Transferases In The Pathogenesis Of Neisseria Meningitidis And N. Gonorrhoeae
Funder
National Health and Medical Research Council
Funding Amount
$574,890.00
Summary
Neisseria meningitidis is the causative agent of meningococcal disease, a rapidly transmissible form of fatal sepsis. The related pathogen, N. gonorrhoeae, causes the sexually transmitted gonorrhoeae and is implicated in the loss of fertility in 10% of patients. This project will analyse the function of a protein necessary for the ability of the both pathogens to cause disease. We will further characterize the function of this protein and determine whether it is a viable candidate for the develo ....Neisseria meningitidis is the causative agent of meningococcal disease, a rapidly transmissible form of fatal sepsis. The related pathogen, N. gonorrhoeae, causes the sexually transmitted gonorrhoeae and is implicated in the loss of fertility in 10% of patients. This project will analyse the function of a protein necessary for the ability of the both pathogens to cause disease. We will further characterize the function of this protein and determine whether it is a viable candidate for the development of drug therapy.Read moreRead less