In cancer cells the normal process of cell death (called apoptosis) is defective, helping abnormal cells to grow and multiply unchecked. The Bak protein is a member of the Bcl-2 family of apoptosis regulators, and plays a pivotal role in mediating cell death. By defining each step in Bak-mediated apoptosis, we aim to better understand how cancer cells accumulate, and how targeting the Bcl-2 family may lead to effective anti-cancer therapeutics.
Role Of Bak And Bax Membrane Anchors In Targeting And Apoptotic Pore Formation.
Funder
National Health and Medical Research Council
Funding Amount
$352,319.00
Summary
In cancer cells the normal process of cell death (called apoptosis) is defective, helping abnormal cells to grow and multiply unchecked. The Bak and Bax proteins are members of the Bcl-2 family of apoptosis regulators, and play a pivotal role in mediating cell death. By defining how these proteins form a pore in mitochondria, the point of no return in cell death, will help the development of novel anti-cancer agents that target the Bcl-2 family in general, and Bak and Bax in particular.
Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to im ....Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to improve models of future seismic hazard in Australia and globally. This will lead to improved predictions of future earthquake impacts in urban and natural environments and development of new paleoseismic techniques.Read moreRead less
An Australian storm wave damage and beach erosion early warning system. This project aims to develop a new coastal hazard early-warning system capability for Australia, to alert coastal communities, emergency managers and coastal engineers to impending storm wave damage and coastal erosion. Emergency preparedness informed by early warning is expected to significantly benefit vulnerable communities and infrastructure along Australia’s coasts.
Fish Jenga: metapopulation management for coastal river fish. This project aims to address the escalating threats to coastal freshwater fish from drought, fire, and other disturbances. The project expects to generate new knowledge on contemporary distributions of NSW coastal freshwater fishes, and will develop models of population dynamics to explore the consequences of alternative water management and disturbance scenarios. The expected outcome of the project is to revolutionise management by r ....Fish Jenga: metapopulation management for coastal river fish. This project aims to address the escalating threats to coastal freshwater fish from drought, fire, and other disturbances. The project expects to generate new knowledge on contemporary distributions of NSW coastal freshwater fishes, and will develop models of population dynamics to explore the consequences of alternative water management and disturbance scenarios. The expected outcome of the project is to revolutionise management by replacing the current practice of managing river basins separately, with a framework that accounts for among-basin linkages that are essential for the long-term persistence of fish populations. Significant benefits include more efficient use of water resources and improved conservation outcomes for native fish.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101154
Funder
Australian Research Council
Funding Amount
$363,996.00
Summary
Regulating cumulative environmental effects: Designing global best practice. This project aims to analyse and evaluate laws regulating cumulative environmental effects in the United States of America, European Union, Canada and Australia. The project will use methods combining law, ethics, and natural and spatial science to develop a framework of globally relevant best practice tools for regulating cumulative effects. The outcomes will increase the capacity of regulators, industry, and the commu ....Regulating cumulative environmental effects: Designing global best practice. This project aims to analyse and evaluate laws regulating cumulative environmental effects in the United States of America, European Union, Canada and Australia. The project will use methods combining law, ethics, and natural and spatial science to develop a framework of globally relevant best practice tools for regulating cumulative effects. The outcomes will increase the capacity of regulators, industry, and the community to better manage common challenges in managing environmental effects and reducing environmental harms.Read moreRead less
Understanding the Drafting-against-Untwisting Process for Engineering Fine and Soft Yarns of Low Hairiness. This research will lead to much improved understanding of a very novel yarn engineering process to achieve fine, soft and low-hairiness yarns from natural fibres. It will demonstrate that Australia not only provides quality wool and cotton fibres, but also leads the world in innovative textile engineering technologies that can enhance the competitive positions of its natural fibres in the ....Understanding the Drafting-against-Untwisting Process for Engineering Fine and Soft Yarns of Low Hairiness. This research will lead to much improved understanding of a very novel yarn engineering process to achieve fine, soft and low-hairiness yarns from natural fibres. It will demonstrate that Australia not only provides quality wool and cotton fibres, but also leads the world in innovative textile engineering technologies that can enhance the competitive positions of its natural fibres in the global fibre market. This research promotes value adding in Australian fibre products by developing advanced yarn engineering technology, which will be of significant national benefit to the multi-billion natural fibre industries in Australia.Read moreRead less
Snails to the rescue! Conservation of Australia’s island invertebrates. This project aims to deliver an exemplar industry network model for conservation on Australia’s islands which are hotspots both of biodiversity and of extinctions. Protecting species on islands is therefore key to securing Australia’s biodiversity. We will secure Norfolk Island's 60 species of land snails via in situ and ex situ conservation with six key industry partners. The project expects to unite conservation actions ac ....Snails to the rescue! Conservation of Australia’s island invertebrates. This project aims to deliver an exemplar industry network model for conservation on Australia’s islands which are hotspots both of biodiversity and of extinctions. Protecting species on islands is therefore key to securing Australia’s biodiversity. We will secure Norfolk Island's 60 species of land snails via in situ and ex situ conservation with six key industry partners. The project expects to unite conservation actions across research, governments, and industry. Expected outcomes of this project include Norfolk Island emerging as a leader in global conservation. This should provide significant benefits such as a model for conservation that is applicable to thousands of isolated, range-restricted invertebrate species across Australia.Read moreRead less
RISER: resilient information systems for emergency response. This project will help to provide emergency managers, responders, and the general public in Australia with access to more timely and relevant information during an emergency. The project will improve the resilience of emergency information systems to the unplanned component failures and uncertain data sources that arise during a disaster.