Fragmentation of rocks upon impact. The project aims to create a new understanding of how rocks fragment upon impact to allow more realistic predictions of rockfall hazards. Rockfall results in loss of human life, damage to infrastructure and economic loss; each year in Australia, millions of dollars are spent on rockfall protection. To mitigate rockfall risk, it is important to understand and predict how blocks break as they fall down a slope. Unfortunately, there is limited data and knowledge ....Fragmentation of rocks upon impact. The project aims to create a new understanding of how rocks fragment upon impact to allow more realistic predictions of rockfall hazards. Rockfall results in loss of human life, damage to infrastructure and economic loss; each year in Australia, millions of dollars are spent on rockfall protection. To mitigate rockfall risk, it is important to understand and predict how blocks break as they fall down a slope. Unfortunately, there is limited data and knowledge on this phenomenon. This project aims to produce a comprehensive, high-quality database of fragmentation events and develop an innovative fragmentation model that can be included in existing rockfall codes. This project is expected to lead to optimised and cost-effective rockfall barrier protection measures.Read moreRead less
Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to im ....Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to improve models of future seismic hazard in Australia and globally. This will lead to improved predictions of future earthquake impacts in urban and natural environments and development of new paleoseismic techniques.Read moreRead less
An Australian storm wave damage and beach erosion early warning system. This project aims to develop a new coastal hazard early-warning system capability for Australia, to alert coastal communities, emergency managers and coastal engineers to impending storm wave damage and coastal erosion. Emergency preparedness informed by early warning is expected to significantly benefit vulnerable communities and infrastructure along Australia’s coasts.
Fish Jenga: metapopulation management for coastal river fish. This project aims to address the escalating threats to coastal freshwater fish from drought, fire, and other disturbances. The project expects to generate new knowledge on contemporary distributions of NSW coastal freshwater fishes, and will develop models of population dynamics to explore the consequences of alternative water management and disturbance scenarios. The expected outcome of the project is to revolutionise management by r ....Fish Jenga: metapopulation management for coastal river fish. This project aims to address the escalating threats to coastal freshwater fish from drought, fire, and other disturbances. The project expects to generate new knowledge on contemporary distributions of NSW coastal freshwater fishes, and will develop models of population dynamics to explore the consequences of alternative water management and disturbance scenarios. The expected outcome of the project is to revolutionise management by replacing the current practice of managing river basins separately, with a framework that accounts for among-basin linkages that are essential for the long-term persistence of fish populations. Significant benefits include more efficient use of water resources and improved conservation outcomes for native fish.Read moreRead less
The effective strength of oceanic plate bounding faults. This project will address the anomalously weak behaviour of the seismically active faults on the boundary of the Australian plate, in three key geodynamic areas. This will constrain the mechanisms which weaken such faults, and produce a model for their effective strength and evolution over geological timescales.
Investigation of atypical bushfire spread driven by the interaction of wind, terrain and fire. Large bushfires continue to pose a significant risk to communities in south-eastern Australia. Despite this, there is still very little known about the processes driving the development of large bushfires. This project aims to improve understanding of extreme fire processes and thus improve mitigation planning, community safety and environmental outcomes.
Shaping a sunburnt country: fire, climate and the Australian landscape. Fire shapes Australia’s landscape, biodiversity and resources. This project aims to quantify the recent history of fire intensity and severity using several novel proxies in the fire-prone landscapes of south-eastern Australia. Calibration of these new proxies to recent wildfires will be used for a better characterisation of fire regimes. This research will be applied to sedimentary archives to investigate how fire regimes h ....Shaping a sunburnt country: fire, climate and the Australian landscape. Fire shapes Australia’s landscape, biodiversity and resources. This project aims to quantify the recent history of fire intensity and severity using several novel proxies in the fire-prone landscapes of south-eastern Australia. Calibration of these new proxies to recent wildfires will be used for a better characterisation of fire regimes. This research will be applied to sedimentary archives to investigate how fire regimes have evolved over the past 100 years. The outcomes will inform debates about the relationship between climatic variability and fire severity, and this will contribute to increase the preparedness of natural resource management to potential future climate and land-use scenarios.Read moreRead less
Prevention Of Multi-drug Resistant Tuberculosis In A High Prevalence Setting: ‘Connecting The DOTS’ In Vietnam
Funder
National Health and Medical Research Council
Funding Amount
$3,382,020.00
Summary
The close contacts of people with multi-drug resistant tuberculosis (MDR-TB) have a high risk of developing the disease. The V-QUIN MDR-TB Trial will evaluate the effectiveness of an oral antibiotic (levofloxacin) in preventing drug resistant TB among infected household contacts of TB patients. Household contacts from 10 Provinces in Vietnam will be randomly allocated to receive six-months of either levofloxacin or a placebo, and then followed for two years to see if they develop tuberculosis.
Multidrug Resistance Protein 1 Inhibitors To Sensitise Cancers To Chemotherapy
Funder
National Health and Medical Research Council
Funding Amount
$840,166.00
Summary
Multidrug resistance protein 1 (MRP1) is often present at high levels in cancer cells, where it pumps chemotherapy drugs back out, causing drug resistance. Inhibitors that block MRP1 would increase the effectiveness of chemotherapy. We have developed MRP1 inhibitors with promising activity in cancer cells and mouse tumours and will now develop these inhibitors for clinical application and commercialisation.