Genetic And Phyisological Regulation Of KIR2DL4 Expression
Funder
National Health and Medical Research Council
Funding Amount
$224,250.00
Summary
Genetic mutations occur frequently but most are deleterious and are lost from the population. Advantageous mutations are selected for and eventually replace the original gene. However, some mutations are advantageous under one set of circumstances and disadvantageous under others. These mutations often reach a high frequency in the population and are maintained along with the original gene. An example of this situation is the mutation in the haemoglobin gene that causes sickle cell anaemia. A si ....Genetic mutations occur frequently but most are deleterious and are lost from the population. Advantageous mutations are selected for and eventually replace the original gene. However, some mutations are advantageous under one set of circumstances and disadvantageous under others. These mutations often reach a high frequency in the population and are maintained along with the original gene. An example of this situation is the mutation in the haemoglobin gene that causes sickle cell anaemia. A single copy of the mutant gene protects against malaria (advantageous) but a double dose of the gene results in sickle cell anaemia, which is fatal. Both the mutant and original gene are maintained in the population as the number of people dying from sickle cell anaemia is less than the number who would die from malaria if the mutant gene did not exist. This phenomenon is known as balancing selection. There are many examples of balancing selection and for each example there is usually a medical condition associated with a double dose of the mutant gene. We have discovered a new example of balancing selection in one of the genes used by the immune system. Very little is known about the function of this gene. In fact the literature abounds with contradictory findings concerning this gene. Our discovery that a mutant gene is present at very high frequency in the population helps explain these contradictory findings and places us in a very strong position to achieve a much better understanding of the function of this gene. We propose to investigate the basic biology of this gene and how it used in the immune system in order to obtain clues as to which medical condition this mutation may be relevant to.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190101389
Funder
Australian Research Council
Funding Amount
$325,000.00
Summary
Imaging, analysing and forecasting Australian hazards with satellites. This project aims to improve Australia’s ability to anticipate geophysical hazards. It will generate a new national capability in the use of satellite radar imagery to monitor and manage geohazards, benefiting all communities. By producing high-resolution maps of ground displacements, the project will assess the controls upon where and why these events occur, and whether they exhibit precursory behaviour. This is the first st ....Imaging, analysing and forecasting Australian hazards with satellites. This project aims to improve Australia’s ability to anticipate geophysical hazards. It will generate a new national capability in the use of satellite radar imagery to monitor and manage geohazards, benefiting all communities. By producing high-resolution maps of ground displacements, the project will assess the controls upon where and why these events occur, and whether they exhibit precursory behaviour. This is the first step towards accurate hazard forecasting and in building Australia's capability for near-real-time geophysical hazard monitoring on a national scale. The outputs will impact upon future recommendations for national earthquake and landslide monitoring and deliver new tools to underpin regulation of resource extraction and inform construction codes.Read moreRead less
Fragmentation of rocks upon impact. The project aims to create a new understanding of how rocks fragment upon impact to allow more realistic predictions of rockfall hazards. Rockfall results in loss of human life, damage to infrastructure and economic loss; each year in Australia, millions of dollars are spent on rockfall protection. To mitigate rockfall risk, it is important to understand and predict how blocks break as they fall down a slope. Unfortunately, there is limited data and knowledge ....Fragmentation of rocks upon impact. The project aims to create a new understanding of how rocks fragment upon impact to allow more realistic predictions of rockfall hazards. Rockfall results in loss of human life, damage to infrastructure and economic loss; each year in Australia, millions of dollars are spent on rockfall protection. To mitigate rockfall risk, it is important to understand and predict how blocks break as they fall down a slope. Unfortunately, there is limited data and knowledge on this phenomenon. This project aims to produce a comprehensive, high-quality database of fragmentation events and develop an innovative fragmentation model that can be included in existing rockfall codes. This project is expected to lead to optimised and cost-effective rockfall barrier protection measures.Read moreRead less
Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to im ....Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to improve models of future seismic hazard in Australia and globally. This will lead to improved predictions of future earthquake impacts in urban and natural environments and development of new paleoseismic techniques.Read moreRead less
An Australian storm wave damage and beach erosion early warning system. This project aims to develop a new coastal hazard early-warning system capability for Australia, to alert coastal communities, emergency managers and coastal engineers to impending storm wave damage and coastal erosion. Emergency preparedness informed by early warning is expected to significantly benefit vulnerable communities and infrastructure along Australia’s coasts.
Discovery Early Career Researcher Award - Grant ID: DE190100062
Funder
Australian Research Council
Funding Amount
$404,000.00
Summary
What's shaking down under? This project aims to determine the underlying cause of recent earthquake activity in central Australia. Of all the stable continents, Australia is surprisingly seismically active, with intra-plate earthquakes occurring relatively frequently. However, these are unpredictable, placing lives and infrastructure at risk. This project offers the opportunity to use a new seismic experiment to improve detection of small events that may warn of a more dangerous earthquake to co ....What's shaking down under? This project aims to determine the underlying cause of recent earthquake activity in central Australia. Of all the stable continents, Australia is surprisingly seismically active, with intra-plate earthquakes occurring relatively frequently. However, these are unpredictable, placing lives and infrastructure at risk. This project offers the opportunity to use a new seismic experiment to improve detection of small events that may warn of a more dangerous earthquake to come, and provide sub-surface imaging of the hidden crustal boundaries and faults that are ultimately responsible. Benefits will include improved hazard assessment, and a new predictive model for exploration that relates regional seismicity, crustal faults, and mineral systems.Read moreRead less