Using Nanotechnology To Improve The Therapeutic Efficacy Of Iron Chelators
Funder
National Health and Medical Research Council
Funding Amount
$692,769.00
Summary
Iron loading disorders (such as thalassaemia) represent an important class of human disease. As part of the treatment for these diseases, the iron needs to be removed and this is often done using iron-binding drugs known as iron chelators. Current chelators are not ideal due to side effects or onerous delivery methods. The goal of this project is to use nanotechnology to develop more effective ways of delivering chelators to improve their effectiveness and reduce toxicity.
Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect ....Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect their activity, and how they affect cellular function, tissue morphology and particle transport in a biological milieu. The project is expected to benefit the advanced manufacturing, veterinary and medical sectors and could lead to new chemotherapeutics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100488
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Cellular dynamics of nanoengineered particles. Nanotechnology has the capacity to drive a new wave of biological innovation through engineering materials at the nanoscale. This project will advance understanding of how nanoengineered materials interact with biological systems to enable the development of nanomaterials for future translational research.
Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The l ....Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The limited tunability of traditional polymers agents makes them unsuitable for this particular application. The multidisciplinary project addresses this significant problem by engineering novel sequences of defined polymer based nanoscale agents to achieve efficient delivery in cells.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100163
Funder
Australian Research Council
Funding Amount
$639,369.00
Summary
Nano-bioscience imaging facility. This project aims to investigate the interactions between nano-engineered materials and biological systems through the use of cutting-edge imaging technologies. The project will consist of an ImageStreamX Imaging Flow Cytometer and a Coherent Anti-Stokes Raman Scattering Microscope. Together these will allow high throughput and label-free imaging of cell-nanomaterial interactions, which will underpin research by leading researchers as well as promoting collabora ....Nano-bioscience imaging facility. This project aims to investigate the interactions between nano-engineered materials and biological systems through the use of cutting-edge imaging technologies. The project will consist of an ImageStreamX Imaging Flow Cytometer and a Coherent Anti-Stokes Raman Scattering Microscope. Together these will allow high throughput and label-free imaging of cell-nanomaterial interactions, which will underpin research by leading researchers as well as promoting collaborations between researchers in the physical and life sciences. This will provide significant benefits, such as the development of new materials for potential applications in nano-bioscience.Read moreRead less
Multifunctional particles for biological applications. This project aims to engineer multifunctional particles, examine their biological interactions and create particles for cell targeting, cell internalisation, subcellular drug release and improved pharmacokinetics. Engineered particles are important for drug delivery in nanomedicine. Although various particle-based delivery systems have been developed, few have been commercialised, largely because of problems challenges associated with biolog ....Multifunctional particles for biological applications. This project aims to engineer multifunctional particles, examine their biological interactions and create particles for cell targeting, cell internalisation, subcellular drug release and improved pharmacokinetics. Engineered particles are important for drug delivery in nanomedicine. Although various particle-based delivery systems have been developed, few have been commercialised, largely because of problems challenges associated with biological barriers. This project will develop a platform for the assemble of particles with tailored properties which are expected to provide insights on particle-biological interactions for particle-based therapeutic delivery.Read moreRead less
Three dimensional nano-lithography: combined electron and ion beam fabrication. By adding one more dimension to a planar (hence two dimensional - 2D) lithography, it will become possible to structure and texture materials in three dimensions (3D) by combining electron beam lithography (2D) and ion beam milling (3D) with the highest precision of several nanometres. This will open new applications in photonics and sensing.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100100
Funder
Australian Research Council
Funding Amount
$440,000.00
Summary
Cytometer by Time of Flight (CyTOF): A New Paradigm in Cytometry. Cytometer by Time of Flight (CyTOF) - a new paradigm in cytometry: The acquisition of a Cytometer by Time of Flight will allow multiparametric characterisation of biological systems and quantitative analysis of nano-bio interactions at the single cell level. The convergence of nanotechnology with biomedicine offers unprecedented opportunities for biological applications, including targeted therapeutics. One of the major challenges ....Cytometer by Time of Flight (CyTOF): A New Paradigm in Cytometry. Cytometer by Time of Flight (CyTOF) - a new paradigm in cytometry: The acquisition of a Cytometer by Time of Flight will allow multiparametric characterisation of biological systems and quantitative analysis of nano-bio interactions at the single cell level. The convergence of nanotechnology with biomedicine offers unprecedented opportunities for biological applications, including targeted therapeutics. One of the major challenges lies in understanding the complex interactions between nanoengineered materials and biological systems.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL120100030
Funder
Australian Research Council
Funding Amount
$2,779,572.00
Summary
Engineering materials for advances in nanomedicine. Nanomedicine is one of the fastest growing areas in nanotechnology. This project will develop next-generation particle systems with engineered properties that are expected to underpin advances in the delivery of therapeutics in the areas of cancer, vaccines, cardiovascular disease and neural health.
Discovery Early Career Researcher Award - Grant ID: DE180100076
Funder
Australian Research Council
Funding Amount
$367,446.00
Summary
Scalable synthesis of smart nanoworms with tailored properties. This project aims to develop next-generation nanomaterials that have a special worm-like shape and can intelligently respond to environmental signals. The project is expected to generate new knowledge in the area of advanced manufacturing utilising innovative approaches in nanotechnology and polymer chemistry. The anticipated outcome is an environmentally friendly technology for industrial production of high value-added nanomaterial ....Scalable synthesis of smart nanoworms with tailored properties. This project aims to develop next-generation nanomaterials that have a special worm-like shape and can intelligently respond to environmental signals. The project is expected to generate new knowledge in the area of advanced manufacturing utilising innovative approaches in nanotechnology and polymer chemistry. The anticipated outcome is an environmentally friendly technology for industrial production of high value-added nanomaterials that may ultimately have a variety of applications including, but not limited to, early diagnosis and efficient therapy of cancer. This should provide benefits to the Australian economy, environment and society.Read moreRead less