Development of planar patch-clamp electrophysiology to investigate liposome-based artificial nanosensor devices. This project aims to characterise the interaction of transport proteins with unsupported lipid bilayer membranes. This will provide the basis for a novel biosensor utilising mechanosensitive ion channels incorporated into an artificial lipid bilayer membrane. To support this outcome, the project will develop the planar patch-clamp electrophysiology recording techniques suitable for l ....Development of planar patch-clamp electrophysiology to investigate liposome-based artificial nanosensor devices. This project aims to characterise the interaction of transport proteins with unsupported lipid bilayer membranes. This will provide the basis for a novel biosensor utilising mechanosensitive ion channels incorporated into an artificial lipid bilayer membrane. To support this outcome, the project will develop the planar patch-clamp electrophysiology recording techniques suitable for liposomes. This provides a significant PhD training opportunity and brings an international focus to the development of planar patch-clamp electrophysiology in Australia. The project has significant commercial potential by developing both the planar patch-clamp electrophysiology techniques for liposomes and producing a novel biomimetic mechanosensitive biosensor.Read moreRead less
High performance conductive mesoporous carbon electrodes: a low energy desalination alternative. The high cost of existing desalination technology has limited its wider application. There is an urgent need for alternatives which require less energy than current methods. The proposed electrosorption process utilising porous carbon electrodes has the advantage of very low energy demand. Electrosorption therefore has the opportunity to become an alternative desalination option for application in a ....High performance conductive mesoporous carbon electrodes: a low energy desalination alternative. The high cost of existing desalination technology has limited its wider application. There is an urgent need for alternatives which require less energy than current methods. The proposed electrosorption process utilising porous carbon electrodes has the advantage of very low energy demand. Electrosorption therefore has the opportunity to become an alternative desalination option for application in a national and global water desalination market. Advancement in water desalination technology has the potential for a profound social, economical and environmental impact. This vital research is aligned with the National Research Priority 1, An Environmentally Sustainable Australia; Priority Goal: Water, A critical resource.Read moreRead less
Development of dense gas technology platforms for the formulation of oral vaccines. This project will aim to develop a technology platform that enables the formulation of vaccines that can be delivered orally and this research has the potential to radically change existing vaccination regimens. The availability of needle-free vaccination also has potential for considerable societal and economic impact in developing countries.
Targeted process development for drug delivery. Matrix assisted ball milling and continuous flow process intensification on rotating surfaces in the form of spinning discs and rotating tubes, and combinations of these, allow the fabrication of nanoparticles for the pharmaceutical industry, with the ability to fine tune the properties of the particles to improve their uptake profiles, while minimising side effects. The research will be conducted through the Centre for Strategic Nano-Fabrication w ....Targeted process development for drug delivery. Matrix assisted ball milling and continuous flow process intensification on rotating surfaces in the form of spinning discs and rotating tubes, and combinations of these, allow the fabrication of nanoparticles for the pharmaceutical industry, with the ability to fine tune the properties of the particles to improve their uptake profiles, while minimising side effects. The research will be conducted through the Centre for Strategic Nano-Fabrication with its science based attention to quality by design for product development at the inception of the science. This, coupled with the involvement of iCeutica which has a strong commercially focused R and D profile, provides a more innovative research culture, and excellent research training. Read moreRead less
Electro-Optical Primers for Safe Use and Clean Manufacturing. Conventional primers contain a mechanically-sensitive primary explosive that is used to detonate the more stable propellant in a bullet. This project aims to address the health and environmental impacts of heavy metals in current primers by replacing them with benign, electrically or optically activated silicon-based materials. Modern semiconductor fabrication techniques will be used to develop safe and clean primers through cost-effe ....Electro-Optical Primers for Safe Use and Clean Manufacturing. Conventional primers contain a mechanically-sensitive primary explosive that is used to detonate the more stable propellant in a bullet. This project aims to address the health and environmental impacts of heavy metals in current primers by replacing them with benign, electrically or optically activated silicon-based materials. Modern semiconductor fabrication techniques will be used to develop safe and clean primers through cost-effective doping and deposition protocols. The expected outcomes of the project include a sovereign primer manufacturing capability for Australia. This will provide a significant strategic advantage and health benefits for law enforcement and defence personnel during live fire training and firing range exercises.Read moreRead less
Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics ....Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics for use in real world applications. The project has two aspects. First, relatively small directed cDNA-bead libraries will be compared to known low-density cDNA microarrays to validate the technique for utility in gene expression profiling. Secondly, large libraries containing short oligonucleotide sequences will be used for de novo sequencing of a complete transcriptome. Proof-of-concept in either case will pave the way for many genomic applications and catapult the technology to 'blockbuster' status.Read moreRead less
Utilisation of dense gas technology for the development of controlled release active pharmaceutical ingredients (API) delivery systems. The aim of this project is to develop an orally administered drug formulation for the treatment of irritable bowel syndrome and other diseases of the colon. Irritable bowel syndrome is a debilitating condition and the cost to society is similar to that of asthma. As such, the project has the potential to have a major impact on society.
Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science an ....Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science and technology infrastructure within Australia, taking it into original and exciting directions, contribute to training young Australian scientists and students, as well as enhance Australia's competitive position in the field of nanobiotechnology.Read moreRead less
Nanostructured Carbon Electrodes. The development of higher capacity energy storage devices is critical to the efficient use of energy. The fundamental knowledge gained in this project will enable the production of the next generation advanced electrode materials for this purpose and hence provide many new commercial opportunities for Australian industry. The project brings together world leaders in their own fields to address a highly multidisciplinary area of research and will provide an excel ....Nanostructured Carbon Electrodes. The development of higher capacity energy storage devices is critical to the efficient use of energy. The fundamental knowledge gained in this project will enable the production of the next generation advanced electrode materials for this purpose and hence provide many new commercial opportunities for Australian industry. The project brings together world leaders in their own fields to address a highly multidisciplinary area of research and will provide an excellent training for PhD students and post doctoral Research Fellows, enabling them to work in and contribute to the development of new nanotechnology industries in Australia.Read moreRead less
Solar Nano-photocatalytic Disinfection and Mineralization of Treated Wastewater from Sewage Treatment Plants. Reuse of the treated wastewater from sewage treatment plants (STPs) has become significantly important in Australia due to dwindling water resources. The poor quality of the wastewater has limited its use for agriculture and aquaculture. This project aims to develop a solar nano-photocatalytic tertiary wastewater treatment process for disinfection and mineralization of the treated waste ....Solar Nano-photocatalytic Disinfection and Mineralization of Treated Wastewater from Sewage Treatment Plants. Reuse of the treated wastewater from sewage treatment plants (STPs) has become significantly important in Australia due to dwindling water resources. The poor quality of the wastewater has limited its use for agriculture and aquaculture. This project aims to develop a solar nano-photocatalytic tertiary wastewater treatment process for disinfection and mineralization of the treated wastewater from STPs, making the wastewater suitable as a water resource. The newly developed nano-fibre catalysts and photocatalytic technology in the teatm will be used and further developed in this novel process. The research will focus on the water quality objectives in terms of technical reliability, and economic and environmental sustainability.Read moreRead less