Development of planar patch-clamp electrophysiology to investigate liposome-based artificial nanosensor devices. This project aims to characterise the interaction of transport proteins with unsupported lipid bilayer membranes. This will provide the basis for a novel biosensor utilising mechanosensitive ion channels incorporated into an artificial lipid bilayer membrane. To support this outcome, the project will develop the planar patch-clamp electrophysiology recording techniques suitable for l ....Development of planar patch-clamp electrophysiology to investigate liposome-based artificial nanosensor devices. This project aims to characterise the interaction of transport proteins with unsupported lipid bilayer membranes. This will provide the basis for a novel biosensor utilising mechanosensitive ion channels incorporated into an artificial lipid bilayer membrane. To support this outcome, the project will develop the planar patch-clamp electrophysiology recording techniques suitable for liposomes. This provides a significant PhD training opportunity and brings an international focus to the development of planar patch-clamp electrophysiology in Australia. The project has significant commercial potential by developing both the planar patch-clamp electrophysiology techniques for liposomes and producing a novel biomimetic mechanosensitive biosensor.Read moreRead less
Development of dense gas technology platforms for the formulation of oral vaccines. This project will aim to develop a technology platform that enables the formulation of vaccines that can be delivered orally and this research has the potential to radically change existing vaccination regimens. The availability of needle-free vaccination also has potential for considerable societal and economic impact in developing countries.
Utilisation of dense gas technology for the development of controlled release active pharmaceutical ingredients (API) delivery systems. The aim of this project is to develop an orally administered drug formulation for the treatment of irritable bowel syndrome and other diseases of the colon. Irritable bowel syndrome is a debilitating condition and the cost to society is similar to that of asthma. As such, the project has the potential to have a major impact on society.
Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science an ....Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science and technology infrastructure within Australia, taking it into original and exciting directions, contribute to training young Australian scientists and students, as well as enhance Australia's competitive position in the field of nanobiotechnology.Read moreRead less
Nanostructured Carbon Electrodes. The development of higher capacity energy storage devices is critical to the efficient use of energy. The fundamental knowledge gained in this project will enable the production of the next generation advanced electrode materials for this purpose and hence provide many new commercial opportunities for Australian industry. The project brings together world leaders in their own fields to address a highly multidisciplinary area of research and will provide an excel ....Nanostructured Carbon Electrodes. The development of higher capacity energy storage devices is critical to the efficient use of energy. The fundamental knowledge gained in this project will enable the production of the next generation advanced electrode materials for this purpose and hence provide many new commercial opportunities for Australian industry. The project brings together world leaders in their own fields to address a highly multidisciplinary area of research and will provide an excellent training for PhD students and post doctoral Research Fellows, enabling them to work in and contribute to the development of new nanotechnology industries in Australia.Read moreRead less
Development of a molecular flash memory for long-term, extremely high-capacity, unpowered data storage. This collaborative project with INTEL will demonstrate an array of Flash-RAM molecular-memory cells capable, at room temperature, of storing a terabit of data on an area of 2 square mm. This data density is more than four orders of magnitude greater than any commercially available technology and unattainable by conventional silicon-based electronics. We will design and optimize the memory cel ....Development of a molecular flash memory for long-term, extremely high-capacity, unpowered data storage. This collaborative project with INTEL will demonstrate an array of Flash-RAM molecular-memory cells capable, at room temperature, of storing a terabit of data on an area of 2 square mm. This data density is more than four orders of magnitude greater than any commercially available technology and unattainable by conventional silicon-based electronics. We will design and optimize the memory cell, develop the synthesis method, synthesize arrays of the memory cells, and develop new molecular addressing technologies.Read moreRead less
Novel methods for enhancing room temperature figure of merit of thermoelectric/thermionic materials for refrigeration applications. With global warming and an increased awareness of climate change, devices such as thermoelectric modules can be part of the solution, particularly if their relative power and efficiency can be increased. The aim of this project is to bring together theoreticians, experimentalists, materials scientists, and industrial partners with complementary expertise to develop ....Novel methods for enhancing room temperature figure of merit of thermoelectric/thermionic materials for refrigeration applications. With global warming and an increased awareness of climate change, devices such as thermoelectric modules can be part of the solution, particularly if their relative power and efficiency can be increased. The aim of this project is to bring together theoreticians, experimentalists, materials scientists, and industrial partners with complementary expertise to develop new techniques and methods for fabricating novel thermoelectric/thermionic materials with high figure of merit, ZT, for solid state refrigeration applications. The success of the project will lead to a 3 to 5 fold increase in the market share of thermoelectric cooler and will have a significant impact on the Australian economy and reduce greenhouse emissions and global warming. Read moreRead less
Heat conduction characterisation of buried insulation layers in silicon-on-insulator systems. This project aims to establish a new technique for the accurate characterisation of thermal conduction in buried insulation layers in advanced silicon-on-insulator (SOI) systems. The success of the project will enable the Australian semiconductor industry to develop high performance SOI systems.
Development of advanced lithium ion battery and battery management system for electric /hybrid electric vehicle applications. This project represents a significant scientific and economic development for Australia as it aims to create advanced, high performing, energy storage devices with a focus on safety, that will provide enormous benefits for the environment. An added advantage will be the establishment of local and national expertise in the area of electrochemical energy storage systems, th ....Development of advanced lithium ion battery and battery management system for electric /hybrid electric vehicle applications. This project represents a significant scientific and economic development for Australia as it aims to create advanced, high performing, energy storage devices with a focus on safety, that will provide enormous benefits for the environment. An added advantage will be the establishment of local and national expertise in the area of electrochemical energy storage systems, that will place Australia at the forefront of lithium ion battery research and development. Flow-on benefits will also be created for Australian organizations involved in the manufacturing of electric vehicles and portable devices.Read moreRead less
Development of new methods for the synthesis of plasmonically-active precious metal rods and shells. This project directly addresses the National Research Priority on building and transforming Australian industries. It will position an Australian manufacturer as the world-leading supplier of speciality precious metal nanoparticles. The project is designed to add significant value to the precious metals products emanating from Australia. In addition to benefiting an existing manufacturing operati ....Development of new methods for the synthesis of plasmonically-active precious metal rods and shells. This project directly addresses the National Research Priority on building and transforming Australian industries. It will position an Australian manufacturer as the world-leading supplier of speciality precious metal nanoparticles. The project is designed to add significant value to the precious metals products emanating from Australia. In addition to benefiting an existing manufacturing operation, it is also expected to assist Australian researchers to capture a leadership role in commercialising new applications for these materials.Read moreRead less