Genetic Polymorphisms Associated With Clinical And Dermoscopic Naevus Signature Patterns
Funder
National Health and Medical Research Council
Funding Amount
$842,841.00
Summary
Melanoma is a form of skin cancer that arises from the cells that produce pigment and is a major public health issue in Australia. We will examine the relationship between the form, structure and colour of existing types of moles and their subsequent risk of developing into melanoma. This study will combine dermoscopy, a non-invasive examination technique, with DNA tests of the genes that determine number of naevi, skin, hair and eye colour, aiding in the early prediction and diagnosis of skin c ....Melanoma is a form of skin cancer that arises from the cells that produce pigment and is a major public health issue in Australia. We will examine the relationship between the form, structure and colour of existing types of moles and their subsequent risk of developing into melanoma. This study will combine dermoscopy, a non-invasive examination technique, with DNA tests of the genes that determine number of naevi, skin, hair and eye colour, aiding in the early prediction and diagnosis of skin cancer.Read moreRead less
Centre Of Research Excellence For The Study Of Naevi
Funder
National Health and Medical Research Council
Funding Amount
$2,496,835.00
Summary
Most melanomas grow adjacent to or within pre-existing benign neoplasms of the skin called naevi. Many studies have shown that the number of nevi on an individual predicts their risk of developing melanoma. New naevi form and existing ones change regularly in children and also adults. While previous work aimed to reduce the burden of melanoma has focussed on malignant tumours, much can be learned from increasing our understanding of tumorigenesis by studying benign tumours such as naevi.
The Ability Of Sunscreens To Protect Against The Induction Of Solar Irradiation-induced Melanocytic Naevi In Vivo.
Funder
National Health and Medical Research Council
Funding Amount
$106,854.00
Summary
Melanoma is an increasing problem in Australia. Strong evidence supports the finding that the number of moles on skin is a good indicator of future melanoma risk and a short term marker of adverse reactions to melanoma-inducing sun exposure in humans. While recommendations for sun protection have been proposed for many years, it is currently unknown what component of sunlight induces melanoma or whether sunscreens protect against the formation of melanoma. Using an animal model for human moles o ....Melanoma is an increasing problem in Australia. Strong evidence supports the finding that the number of moles on skin is a good indicator of future melanoma risk and a short term marker of adverse reactions to melanoma-inducing sun exposure in humans. While recommendations for sun protection have been proposed for many years, it is currently unknown what component of sunlight induces melanoma or whether sunscreens protect against the formation of melanoma. Using an animal model for human moles of the skin we aim in contributing to the answers of these two questions .Read moreRead less
Identification Of The Molecular Hallmarks Of Naevi Progressing To Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Melanomas are amongst the most commonly occurring cancers in Australia with >136,000 people living with a previous melanoma diagnosis. One of the highest risk factors for developing melanoma is having a high number of moles (or naevi). It is therefore important to fully understand how and why naevi develop into melanoma. It is hoped that early detection markers will be identified which will help identify early melanomas and as such improve patient outcome.
Exploring The Causal Pathways To Cutaneous Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$159,171.00
Summary
Melanomas are cancers arising from the pigment cells of the skin, and are among the most commonly occurring cancers in this country. Each year, more than 8000 Australians are diagnosed with invasive melanoma, resulting in some 900 deaths annually. Survival from melanoma is high if the disease is detected early (5 yr survival for thin melanomas-94%), however survival rates for thicker tumours are significantly worse, and for metastatic disease, very poor (<10%). Sunlight is the principal facto ....Melanomas are cancers arising from the pigment cells of the skin, and are among the most commonly occurring cancers in this country. Each year, more than 8000 Australians are diagnosed with invasive melanoma, resulting in some 900 deaths annually. Survival from melanoma is high if the disease is detected early (5 yr survival for thin melanomas-94%), however survival rates for thicker tumours are significantly worse, and for metastatic disease, very poor (<10%). Sunlight is the principal factor which causes this disease, although there is increasing evidence that the role of sunlight in causing melanoma is not the same for all people who develop this disease. A new hypothesis proposes that the malignant course of melanomas may reflect their causal origins, with melanomas induced by chronic sunlight exposure perhaps being more aggressive than other melanomas. We will undertake a large study of patients with melanoma to investigate both the causal pathways to melanoma and their influence on markers of tumour aggressiveness. We will capture detailed information about the microscopic appearance of the melanomas from pathologists at the time of diagnosis, and marry this to the information reported by the patients about their past history of sun exposure. When complete, this study will provide new information about the causes of melanoma. Such knowledge is crucial to controlling and preventing this cancer.Read moreRead less