New drugs for cancer therapy that overcome resistance to standard chemotherapeutics and stop the spread of cancer are essential to develop. My preliminary studies discovered a strategy to increase the activity and delivery of our novel compounds to enhance the killing of cancer cells. I will design innovative agents in an effort to provide more effective therapeutics with fewer side effects to reduce the pain of cancer patients undertaking chemotherapy who are in the battle of their lives.
Trafficking Of The Malaria Parasites Chloroquine Resistance Transporter
Funder
National Health and Medical Research Council
Funding Amount
$310,075.00
Summary
The malaria parasite is a single-celled organism which invades the red blood cells of its host. The aim of this project is to gain a better understanding of the protein underlying the resistance of the parasite to the drug chloroquine. This protein is located at an internal membrane within the parasite, but the elements which facilitate this localization are not known. This study will give valuable insights into the factors influencing the trafficking of parasite proteins to different membranes.
Novel Antibiotics Targeting Bacterial Secretion Systems
Funder
National Health and Medical Research Council
Funding Amount
$303,357.00
Summary
Infection caused by pathogenic bacteria is a major health concern. Strains of bacteria are constantly becoming resistant to front line antibiotics, driving the need for more effective treatments. A drug target that is not currently utilized in clinical treatment is a family of molecular nano-machines embedded in the bacterial cell wall. These machines are called sectretins. The aim of this research is to fundamentally understand their molecular architecture in order to guide the design of potent ....Infection caused by pathogenic bacteria is a major health concern. Strains of bacteria are constantly becoming resistant to front line antibiotics, driving the need for more effective treatments. A drug target that is not currently utilized in clinical treatment is a family of molecular nano-machines embedded in the bacterial cell wall. These machines are called sectretins. The aim of this research is to fundamentally understand their molecular architecture in order to guide the design of potent and selective inhibitory drugs.Read moreRead less