Macrophages: A Therapeutic Target In Peritoneal Dialysis-induced Fibrosis?
Funder
National Health and Medical Research Council
Funding Amount
$593,888.00
Summary
Fibrosis (scar tissue) in the abdominal cavity is a common side-effect of peritoneal dialysis (a treatment for kidney failure), and results in a life-threatening loss of dialysis function. The cells causing the fibrosis are uncertain. This project asks: Are inflammatory cells (macrophages) the source of peritoneal scar tissue? What regulates the fibrotic process? Answers may lead to strategies to prevent fibrosis induced by peritoneal dialysis, abdominal surgery or other causes.