Remote Ischaemic Preconditioning And Its Effect On Coronary Physiology And Platelet And Leukocyte Activation.
Funder
National Health and Medical Research Council
Funding Amount
$124,608.00
Summary
Remote ischaemic preconditioning (RIPC) is a novel treatment which can improve patient outcomes after a heart attack, undergoing coronary stenting or bypass surgery. The mechanisms by which RIPC confers this cardio-protection is not clear. We will study the effects of RIPC on platelet activity and the flow of blood in the arteries that supply the heart. Understanding RIPC may open new avenues for treatment of patients with coronary artery disease, one of the major causes of death in Australia.
Feasibility Of Using Pre-hospital Point-of-care Troponin And Paramedic Risk Assessment In Patients With Chest Pain Without ST-elevation
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Non-traumatic chest pain is the leading cause of ambulance services use in Victoria. Currently, there is no protocol for paramedics to determine which patients are high risk and suffering a minor heart attack, which results in delays in treatment. The aim of this project is to assess the feasibility of a risk assessment tool, including the use of point-of-care blood testing to detect heart attacks, to accurately risk stratify chest pain patients in the pre-hospital setting.
CAMERA-MRI II: Catheter Ablation Versus Medical Rate Control In Atrial Fibrillation With Systolic Heart Failure And Myocardial Fibrosis - An MRI Guided Multi-Centre Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Atrial fibrillation (AF) is an irregular heart rhythm commonly seen in patients with a weakened heart muscle. Symptoms and heart function may improve if the rhythm is restored through a catheter ablation procedure. This study will assess whether this procedure improves the function of the heart in those with AF where there is weakness and scarring of the heart. We hope to better determine which patients are best suited and will derive the most benefit from this procedure.
The Effect Of Renal Transplantation And Extended Hours Haemodialysis On Cardiac MRI And Biomarkers.
Funder
National Health and Medical Research Council
Funding Amount
$107,750.00
Summary
Patients with chronic kidney disease (CKD) are at increased risk for cardiovascular disease (CVD). Asymptomatic patients demonstrate changes in cardiac imaging and elevation of cardiac biomarkers which predict outcome. This study will investigate serial cardiac imaging and cardiac biomarkers in patients undergoing live donor renal transplantation and extended hours haemodialysis. Results will enhance our understanding of cardiovascular disease in CKD leading to improved patient outcomes.
Platelet Derived Growth Factor Mediated Activation And Rejuvenation Of Endogenous Cardiac Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$102,345.00
Summary
The burden of heart failure is underpinned by the heart’s limited capacity for self-repair after injury. Recent evidence shows that PDGF can improve heart function by activating and rejuvenating resident heart stem cells. This project will build on over a decade of preliminary work in mice, validating our results in a preclinical large animal model. Outcomes of this project include expedited progression of this promising therapy where thousands of heart failure patients could one-day benefit.
Sharpening The Epidemiological Sword Against Ocular Trauma To Help Improve Management And Predict The Visual Outcomes, Contributing To The Development Of Prevention
Funder
National Health and Medical Research Council
Funding Amount
$59,168.00
Summary
Eye injury is the leading cause of monocular blindness internationally. Vision loss has devastating consequences, both financial and social. My research aims to develop a comprehensive international register for eye injury. Working with key international partners we will conduct a large-scale retrospective review to validate our data collection tool. Our aim is to revise outdated methods of scoring eye injury to better predict outcomes and improve management and treatment of eye injury.
Revealing The Roadblocks: Timely ST-segment Elevation Myocardial Infarction (STEMI) Management Over Total Ischaemic Time In Metropolitan, Regional And Rural Victoria.
Funder
National Health and Medical Research Council
Funding Amount
$72,768.00
Summary
Cardiovascular disease kills one Australian every 12 minutes. Coordinated and prompt medical treatment of heart attack is essential in preventing mortality. This study will identify contributing factors of delay from a frontline clinician and hospital perspective. It is anticipated by understanding the impact these factors have on the delivery of heart attack care, an evidence base is built to support the various clinicians involved, and improve this complex process of care across Victoria.
Double Blind, Randomised Controlled Trial Assessing The Efficacy Of Endothelin-1 Receptor Antagonism In Preventing Peri-procedural Myonecrosis In Patients With Non-ST Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
Funder
National Health and Medical Research Council
Funding Amount
$124,608.00
Summary
While the focus in the treatment of coronary artery disease has primarily been on the large vessels in the heart, vessels of small calibre may also play a significant role in patients with angina, heart attack, and muscle injury related to a stenting procedure.This project aims elucidate the possible mechanisms which cause dysfunction in these small vessels. I also hope to find a treatment strategy which may benefit patients with small vessel problems and thus improve their overall outcome.
What Is The Function Of The Tibialis Posterior Muscle And Tendon During Walking And How Does It Affect Disorders Of The Foot
Funder
National Health and Medical Research Council
Funding Amount
$110,235.00
Summary
The tibialis posterior (TP) muscle is important for foot function and is often implicated in foot and ankle problems. We will investigate the function of TP during gait with specific reference to foot posture. In particular we will examine the mechanical function of the muscle and tendon in different foot postures and commonly used treatment modalities such as (footwear and foot orthoses).