Discovery and characterisation of novel spider-venom peptides targeting the human sodium ion channel Nav1.7. Drugs that selectively block the human sodium ion channel Nav1.7 are likely to be powerful analgesics for treating a wide variety of pain conditions. However, it has proved difficult to obtain selective blockers of this channel. The aim of this project is to determine whether spider-venoms might provide a source of highly selective Nav1.7 blockers.
High performance cast magnesium alloys. Reducing the weight of cars, particularly their engines, enables substantial reductions in fuel consumption and greenhouse gas emissions. A new generation of magnesium alloys will be developed by this project for the manufacture of considerably lighter components with improved mechanical performance for powertrain and structural applications.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100071
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
In-situ elevated temperature nano-indentation. In-situ elevated temperature nano-indentation: Nano-indentation has revolutionised the characterisation of the mechanical properties of materials. It permits the elastic, plastic and cracking response to be probed at the nano-scale. This project will provide a state-of-the-art Hysitron nano-indenter configured to permit isothermal elevated temperature operation (up to 650 degrees Celsius). The unit will be the only one in Australia with this capabil ....In-situ elevated temperature nano-indentation. In-situ elevated temperature nano-indentation: Nano-indentation has revolutionised the characterisation of the mechanical properties of materials. It permits the elastic, plastic and cracking response to be probed at the nano-scale. This project will provide a state-of-the-art Hysitron nano-indenter configured to permit isothermal elevated temperature operation (up to 650 degrees Celsius). The unit will be the only one in Australia with this capability and amongst the few available globally. Temperature is the single most important parameter in material processing. This facility will permit the assembled team to be among the first in the world to apply this technique to the development of new materials with superior processing performance in addition to enhanced behaviour in service.Read moreRead less