Novel Strategies To Promote Myelin Repair In The Brain
Funder
National Health and Medical Research Council
Funding Amount
$597,865.00
Summary
Demyelinating diseases of the central nervous system such as multiple sclerosis have a lifelong impact and devastating impact on quality of life. We have identified that a growth factor, brain derived neurotrophic factor (BDNF), plays an important role in promoting myelination during development. We will investigate the potential of translating these findings into effective clinical treatment, by characterising the efficacy of BDNF in promoting CNS remyelination after a demyelinating insult.
Investigating the functional interaction between vasopressin and angiotensin receptors. Kidney disease resulting from diabetes is a major health issue for Australians, and indigenous Australians in particular. This project aims to enable improved therapies to be developed, as well as better inform doctors regarding the use of potential combinations of existing pharmaceuticals to treat this condition.
Future copper metallurgy for the age of e-mobility and the circular economy. Copper, nickel, cobalt, chromium and tin metals are essential for the manufacture of new battery materials, electrical and electronic devices and technologies that will enable the global transition to sustainable energy systems. There are major technical challenges associated with the industrial scale high temperature production, separation and recycling of these metals. The aim of the present study is develop advanced ....Future copper metallurgy for the age of e-mobility and the circular economy. Copper, nickel, cobalt, chromium and tin metals are essential for the manufacture of new battery materials, electrical and electronic devices and technologies that will enable the global transition to sustainable energy systems. There are major technical challenges associated with the industrial scale high temperature production, separation and recycling of these metals. The aim of the present study is develop advanced chemical thermodynamic databases and models that can be used to predict the outcomes of these complex chemical reactions, and in doing so provide the industry with the vital fundamental scientific information and tools needed to be able to design and improve new, more efficient metal production and recycling technologies. Read moreRead less
Sustainable copper metallurgy and recycling – saving energy and resources. This project aims to develop new, powerful and sophisticated, computer-based models that can reliably predict the results of chemical reactions in complex, high temperature metal production processes. This project expects to use these models, initially applied to copper smelting systems, to enable the improved recycling of other valuable metals. These models should be able to be applied to a wide range of technologies use ....Sustainable copper metallurgy and recycling – saving energy and resources. This project aims to develop new, powerful and sophisticated, computer-based models that can reliably predict the results of chemical reactions in complex, high temperature metal production processes. This project expects to use these models, initially applied to copper smelting systems, to enable the improved recycling of other valuable metals. These models should be able to be applied to a wide range of technologies used in the metallurgical industry as most of the world’s metals are produced by these pyrometallurgical processes. This should provide significant benefits such as substantial improvements in productivity and process efficiencies, whilst at the same time delivering energy savings and improved use of valuable metal resources.Read moreRead less
Fish venom as a model system for the molecular evolution of defensive toxins. The key aim of this study is to undertake a thorough investigation of venoms found in distinct fish lineages, including enigmatic species such as venomous and medically important species such as the stonefish. By characterising the biodiversity of toxins found in the venoms of different fish, the evolutionary history of venom in this major vertebrate lineage can be revealed. The investigations proposed here will also d ....Fish venom as a model system for the molecular evolution of defensive toxins. The key aim of this study is to undertake a thorough investigation of venoms found in distinct fish lineages, including enigmatic species such as venomous and medically important species such as the stonefish. By characterising the biodiversity of toxins found in the venoms of different fish, the evolutionary history of venom in this major vertebrate lineage can be revealed. The investigations proposed here will also determine the functional activities of different venoms and their components. This will not only help the understanding of the medical consequences of the annual thousands of fish envenomings but also explore a largely unstudied resource for the discovery of new pharmacological diagnostics and therapeutics.Read moreRead less