Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100165
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Thermal and mechanical simulation laboratory for light metals. The creation of a thermal and mechanical simulation laboratory for light metals will provide the critical infrastructure needed for generating new alloys and composites. This will extend Australia's competitive advantage in the design of better alloys for expanding applications in the construction, packaging, automotive and aerospace sectors.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100115
Funder
Australian Research Council
Funding Amount
$430,000.00
Summary
Facility for the development of new lightweight extruded alloys and structures. This will be Australia's only large-scale, research-dedicated extrusion facility. It is expected to lead to the development of new light metal alloys, metal-matrix composites, micro-truss structures and powder base metals for structural and biomedical applications.
Advanced high strength steels produced by energy efficient direct strip casting. Over one billion tonnes of steel is produced every year and one method of reducing the environmental footprint of this production is through strip casting. This process reduces the energy required to process liquid steel into thin sheet product by an astounding 90 per cent. This proposal aims to expand the application of this technology to new steel grades.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883078
Funder
Australian Research Council
Funding Amount
$356,000.00
Summary
Liquid Chromatography Tandem Mass Spectrometry Steroid Analysis Facility. This first of a new generation of ultra-sensitive analytical mass spectrometers for small molecules will be established as a national assay facility allowing all Australian researchers open access to a new dimension of highly accurate and simultaneous measurements of multiple bodily chemicals such as steroids, vitamins and hormones. It is crucial to developing new knowledge in basic, developmental and pathological cell bio ....Liquid Chromatography Tandem Mass Spectrometry Steroid Analysis Facility. This first of a new generation of ultra-sensitive analytical mass spectrometers for small molecules will be established as a national assay facility allowing all Australian researchers open access to a new dimension of highly accurate and simultaneous measurements of multiple bodily chemicals such as steroids, vitamins and hormones. It is crucial to developing new knowledge in basic, developmental and pathological cell biology and for underpinning commercial developments of new molecular targets for therapeutic drugs for many diseases including cancer, cardiovascular disease and reproductive disorders. This facility is pivotal to maintaining international competitiveness in many areas of biological research in national priority areas.Read moreRead less
Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric ....Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric oxide regulates large artery stiffness and we believe that other endothelial mediators are also important regulators. Therefore, we aim to explore this in a series of studies. Regulation of stiffness of large arteries will improve treatment of age-related cardiovascular disease (eg isolated systolic hypertension)Read moreRead less
Defining mechanisms of action of novel alpha-conotoxins at nicotinic receptor-channels. Marine snails from the waters off the Australian coast produce an amazing variety of mini-proteins in their venoms called conotoxins that they use to capture prey. These conotoxins bind very specifically to receptors in our body associated with the transmission of nerve signals. We will use natural and synthetically modified conotoxins to selectively block particular types of neuronal 'receptors' to gain a gr ....Defining mechanisms of action of novel alpha-conotoxins at nicotinic receptor-channels. Marine snails from the waters off the Australian coast produce an amazing variety of mini-proteins in their venoms called conotoxins that they use to capture prey. These conotoxins bind very specifically to receptors in our body associated with the transmission of nerve signals. We will use natural and synthetically modified conotoxins to selectively block particular types of neuronal 'receptors' to gain a greater understanding of how the nervous system functions. This knowledge will help in the design of new drugs to treat a variety of diseases and disorders. Essentially we will use a chemical armoury developed by the cone snail to design state-of-the-art mini-protein drugs.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH130100017
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub for Australian Steel Manufacturing. ARC Research Hub for Australian Steel Manufacturing. The aim of this Research Hub is to develop breakthrough process and product innovations to enable the Australian steel industry to improve its global competitiveness. Based on an integrated, value chain-wide approach to innovation in the steel sector the Research Hub includes projects on innovation strategy and management, customer-focused product development, innovation in coating and surfa ....ARC Research Hub for Australian Steel Manufacturing. ARC Research Hub for Australian Steel Manufacturing. The aim of this Research Hub is to develop breakthrough process and product innovations to enable the Australian steel industry to improve its global competitiveness. Based on an integrated, value chain-wide approach to innovation in the steel sector the Research Hub includes projects on innovation strategy and management, customer-focused product development, innovation in coating and surface engineering technology, and economic and environmental sustainability of iron and steelmaking.Read moreRead less
High performance cast magnesium alloys. Reducing the weight of cars, particularly their engines, enables substantial reductions in fuel consumption and greenhouse gas emissions. A new generation of magnesium alloys will be developed by this project for the manufacture of considerably lighter components with improved mechanical performance for powertrain and structural applications.
Micromechanic modelling and analysis of the dynamics of non-spherical particles coupled with fluid flow. This project aims to develop advanced theories and mathematical models to describe the packing and flow of non-spherical particles coupled with fluid flow. This will be achieved through a combined theoretical and experimental program, involving the use of advanced discrete particle simulation and detailed analysis of packing/flow structures, particle-particle and particle-fluid interactions a ....Micromechanic modelling and analysis of the dynamics of non-spherical particles coupled with fluid flow. This project aims to develop advanced theories and mathematical models to describe the packing and flow of non-spherical particles coupled with fluid flow. This will be achieved through a combined theoretical and experimental program, involving the use of advanced discrete particle simulation and detailed analysis of packing/flow structures, particle-particle and particle-fluid interactions at a particle scale. Research outcomes including theories, computer models and simulation techniques will be applied to representative industrial operations of importance to Australia's economic and technological future.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH140100035
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub for Computational Particle Technology. ARC Research Hub for Computational Particle Technology. This research hub aims to develop and apply advanced theories and mathematical models to design and optimise particulate and multiphase processes that are widely used in the minerals and metallurgical industries. This should be achieved through detailed analysis of the fundamentals governing fluid flow, heat and mass transfer at different time and length scales, facilitated by various ....ARC Research Hub for Computational Particle Technology. ARC Research Hub for Computational Particle Technology. This research hub aims to develop and apply advanced theories and mathematical models to design and optimise particulate and multiphase processes that are widely used in the minerals and metallurgical industries. This should be achieved through detailed analysis of the fundamentals governing fluid flow, heat and mass transfer at different time and length scales, facilitated by various novel research techniques. Research outcomes including theories, computer models and simulation techniques, as well as well-trained young researchers, should have a significant impact across a range of industries of vital importance to Australia’s economic and technological future, including the minerals, metallurgical, materials, chemical, energy, pharmaceutical and environment sectors.Read moreRead less