Advanced high strength steels produced by energy efficient direct strip casting. Over one billion tonnes of steel is produced every year and one method of reducing the environmental footprint of this production is through strip casting. This process reduces the energy required to process liquid steel into thin sheet product by an astounding 90 per cent. This proposal aims to expand the application of this technology to new steel grades.
Defining mechanisms of action of novel alpha-conotoxins at nicotinic receptor-channels. Marine snails from the waters off the Australian coast produce an amazing variety of mini-proteins in their venoms called conotoxins that they use to capture prey. These conotoxins bind very specifically to receptors in our body associated with the transmission of nerve signals. We will use natural and synthetically modified conotoxins to selectively block particular types of neuronal 'receptors' to gain a gr ....Defining mechanisms of action of novel alpha-conotoxins at nicotinic receptor-channels. Marine snails from the waters off the Australian coast produce an amazing variety of mini-proteins in their venoms called conotoxins that they use to capture prey. These conotoxins bind very specifically to receptors in our body associated with the transmission of nerve signals. We will use natural and synthetically modified conotoxins to selectively block particular types of neuronal 'receptors' to gain a greater understanding of how the nervous system functions. This knowledge will help in the design of new drugs to treat a variety of diseases and disorders. Essentially we will use a chemical armoury developed by the cone snail to design state-of-the-art mini-protein drugs.Read moreRead less
Micromechanic modelling and analysis of the dynamics of non-spherical particles coupled with fluid flow. This project aims to develop advanced theories and mathematical models to describe the packing and flow of non-spherical particles coupled with fluid flow. This will be achieved through a combined theoretical and experimental program, involving the use of advanced discrete particle simulation and detailed analysis of packing/flow structures, particle-particle and particle-fluid interactions a ....Micromechanic modelling and analysis of the dynamics of non-spherical particles coupled with fluid flow. This project aims to develop advanced theories and mathematical models to describe the packing and flow of non-spherical particles coupled with fluid flow. This will be achieved through a combined theoretical and experimental program, involving the use of advanced discrete particle simulation and detailed analysis of packing/flow structures, particle-particle and particle-fluid interactions at a particle scale. Research outcomes including theories, computer models and simulation techniques will be applied to representative industrial operations of importance to Australia's economic and technological future.Read moreRead less
The combined use of proteomics and small molecules for target identification and pathway analysis. This project intends to investigate how a series of new small molecules identified from our research to improve the metabolic effects of insulin. This project will integrate medicinal chemistry with proteomics and metabolic biology to identify the cellular targets and their mechanism of action.