Discovery and characterisation of novel spider-venom peptides targeting the human sodium ion channel Nav1.7. Drugs that selectively block the human sodium ion channel Nav1.7 are likely to be powerful analgesics for treating a wide variety of pain conditions. However, it has proved difficult to obtain selective blockers of this channel. The aim of this project is to determine whether spider-venoms might provide a source of highly selective Nav1.7 blockers.
Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing an ....Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing and reduced-order state observer, supported by lab/plant experiments, and collaborating with two industry partners from coal and steel industries. The project outcomes including codes, models and raceway control strategies can help promote Australian metallurgical coal's global markets and ultimately the Australian economy.Read moreRead less
New Lead-Free Brass Solutions for Drinking Water Applications. The aim of this Linkage Project is to provide viable material solutions to address the health problem of Lead-contamination in drinking water arising from Leaded-brass plumbing products and the impact Lead-removal from brass will have on the brass industry. In order to achieve this, this project engages leading multidisciplinary researchers along with Australian and international industry partners from across the brass industry suppl ....New Lead-Free Brass Solutions for Drinking Water Applications. The aim of this Linkage Project is to provide viable material solutions to address the health problem of Lead-contamination in drinking water arising from Leaded-brass plumbing products and the impact Lead-removal from brass will have on the brass industry. In order to achieve this, this project engages leading multidisciplinary researchers along with Australian and international industry partners from across the brass industry supply and sales network. This project seeks to identify and harness the key material-product attributes required to develop and implement new, lead-free alloy alternatives that meet health-compliance, production and commercial viability, that offer benefits across the industry network and health benefits to society.Read moreRead less
High performance cast magnesium alloys. Reducing the weight of cars, particularly their engines, enables substantial reductions in fuel consumption and greenhouse gas emissions. A new generation of magnesium alloys will be developed by this project for the manufacture of considerably lighter components with improved mechanical performance for powertrain and structural applications.
Origin and impact of solute clustering in light alloys. This project is designed to provide a physical metallurgy platform for understanding and interpreting the role of clusters of micro-alloying elements in precipitation in light alloys and aiding new alloy development. Phase transformations play an important role in determining the mechanical properties of many engineering materials. Understanding the origin and impact of solute clustering in phase transformations is crucial for achieving unp ....Origin and impact of solute clustering in light alloys. This project is designed to provide a physical metallurgy platform for understanding and interpreting the role of clusters of micro-alloying elements in precipitation in light alloys and aiding new alloy development. Phase transformations play an important role in determining the mechanical properties of many engineering materials. Understanding the origin and impact of solute clustering in phase transformations is crucial for achieving unprecedented properties in these materials. This project plans to combine atomic-scale characterisation and multi-scale computation to reveal the geometry and energetics of solute clusters and cluster-assisted nucleation in light alloys based on aluminium and magnesium. Applications may include the development of stronger and less costly metallic materials for the aerospace, aircraft and automotive industries.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH200100005
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub for Australian Steel Innovation. The Hub’s overarching goal is to support the transition of Australia’s steel manufacturing industry to a more sustainable, competitive and resilient position based on the creation of new, higher value-added products and more advanced manufacturing processes. It anticipates delivering original, innovative research designed to enable a necessary technological shift in the supply chain through integrating advanced enabling technologies in large and ....ARC Research Hub for Australian Steel Innovation. The Hub’s overarching goal is to support the transition of Australia’s steel manufacturing industry to a more sustainable, competitive and resilient position based on the creation of new, higher value-added products and more advanced manufacturing processes. It anticipates delivering original, innovative research designed to enable a necessary technological shift in the supply chain through integrating advanced enabling technologies in large and small businesses, developing step-change performance in anti-corrosion treatments and coating lines, generating more functional and durable products, and increasing resource intensities. It expects to train a more skillful and diverse workforce that will be critical in achieving this transformation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100071
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
In-situ elevated temperature nano-indentation. In-situ elevated temperature nano-indentation: Nano-indentation has revolutionised the characterisation of the mechanical properties of materials. It permits the elastic, plastic and cracking response to be probed at the nano-scale. This project will provide a state-of-the-art Hysitron nano-indenter configured to permit isothermal elevated temperature operation (up to 650 degrees Celsius). The unit will be the only one in Australia with this capabil ....In-situ elevated temperature nano-indentation. In-situ elevated temperature nano-indentation: Nano-indentation has revolutionised the characterisation of the mechanical properties of materials. It permits the elastic, plastic and cracking response to be probed at the nano-scale. This project will provide a state-of-the-art Hysitron nano-indenter configured to permit isothermal elevated temperature operation (up to 650 degrees Celsius). The unit will be the only one in Australia with this capability and amongst the few available globally. Temperature is the single most important parameter in material processing. This facility will permit the assembled team to be among the first in the world to apply this technique to the development of new materials with superior processing performance in addition to enhanced behaviour in service.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100087
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Enabling future technology by building light element analysis capability: a light element optimised ultra-high resolution electron microprobe. The capability to characterise the chemistry of materials at very small scales is critical for geologists, metallurgists and materials scientists. The new instrument is world-leading technology that will enable analysis of light element-rich materials at extremely high resolution (< 50 nanometers) with very low detection limits.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100078
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Establishment of a comprehensive regional biophysical analysis facility. Interactions between molecules are needed for cells to function correctly. This facility will permit comprehensive molecular characterisation as well as research into the fundamentals of how molecules interact.