Discovery and characterisation of novel spider-venom peptides targeting the human sodium ion channel Nav1.7. Drugs that selectively block the human sodium ion channel Nav1.7 are likely to be powerful analgesics for treating a wide variety of pain conditions. However, it has proved difficult to obtain selective blockers of this channel. The aim of this project is to determine whether spider-venoms might provide a source of highly selective Nav1.7 blockers.
High performance cast magnesium alloys. Reducing the weight of cars, particularly their engines, enables substantial reductions in fuel consumption and greenhouse gas emissions. A new generation of magnesium alloys will be developed by this project for the manufacture of considerably lighter components with improved mechanical performance for powertrain and structural applications.
Origin and impact of solute clustering in light alloys. This project is designed to provide a physical metallurgy platform for understanding and interpreting the role of clusters of micro-alloying elements in precipitation in light alloys and aiding new alloy development. Phase transformations play an important role in determining the mechanical properties of many engineering materials. Understanding the origin and impact of solute clustering in phase transformations is crucial for achieving unp ....Origin and impact of solute clustering in light alloys. This project is designed to provide a physical metallurgy platform for understanding and interpreting the role of clusters of micro-alloying elements in precipitation in light alloys and aiding new alloy development. Phase transformations play an important role in determining the mechanical properties of many engineering materials. Understanding the origin and impact of solute clustering in phase transformations is crucial for achieving unprecedented properties in these materials. This project plans to combine atomic-scale characterisation and multi-scale computation to reveal the geometry and energetics of solute clusters and cluster-assisted nucleation in light alloys based on aluminium and magnesium. Applications may include the development of stronger and less costly metallic materials for the aerospace, aircraft and automotive industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100071
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
In-situ elevated temperature nano-indentation. In-situ elevated temperature nano-indentation: Nano-indentation has revolutionised the characterisation of the mechanical properties of materials. It permits the elastic, plastic and cracking response to be probed at the nano-scale. This project will provide a state-of-the-art Hysitron nano-indenter configured to permit isothermal elevated temperature operation (up to 650 degrees Celsius). The unit will be the only one in Australia with this capabil ....In-situ elevated temperature nano-indentation. In-situ elevated temperature nano-indentation: Nano-indentation has revolutionised the characterisation of the mechanical properties of materials. It permits the elastic, plastic and cracking response to be probed at the nano-scale. This project will provide a state-of-the-art Hysitron nano-indenter configured to permit isothermal elevated temperature operation (up to 650 degrees Celsius). The unit will be the only one in Australia with this capability and amongst the few available globally. Temperature is the single most important parameter in material processing. This facility will permit the assembled team to be among the first in the world to apply this technique to the development of new materials with superior processing performance in addition to enhanced behaviour in service.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100087
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Enabling future technology by building light element analysis capability: a light element optimised ultra-high resolution electron microprobe. The capability to characterise the chemistry of materials at very small scales is critical for geologists, metallurgists and materials scientists. The new instrument is world-leading technology that will enable analysis of light element-rich materials at extremely high resolution (< 50 nanometers) with very low detection limits.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100078
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Establishment of a comprehensive regional biophysical analysis facility. Interactions between molecules are needed for cells to function correctly. This facility will permit comprehensive molecular characterisation as well as research into the fundamentals of how molecules interact.