Future polymetallic processing through lead smelting, recycling, refining. The aim of the project is to provide new data and thermodynamic modelling tools to be used in the development of the next generation of lead metal smelting, refining and recycling processes used to recycle electronic materials, process hazardous wastes and recover valuable metals. The intention is to combine recently developed experimental techniques with the latest advances in FactSage chemical thermodynamic modelling to ....Future polymetallic processing through lead smelting, recycling, refining. The aim of the project is to provide new data and thermodynamic modelling tools to be used in the development of the next generation of lead metal smelting, refining and recycling processes used to recycle electronic materials, process hazardous wastes and recover valuable metals. The intention is to combine recently developed experimental techniques with the latest advances in FactSage chemical thermodynamic modelling to overcome long-standing experimental and modelling obstacles. The new experimental data and databases are intended to provide important information on high-temperature chemistry of complex phase equilibria and on the distribution of minor elements in multiphase systems.Read moreRead less
Coke integrity in blast furnace ironmaking: understanding and technology development. This project's expected outcomes will lead to optimised coke consumption for the blast furnace and to a more competitive steel manufacturing sector, through improved and rational criteria for selection of carbonaceous materials. This will result in more efficient ironmaking with significant operational, economical and environmental benefits.
The use of Australian magnetite ore in advanced ironmaking. The project will study reduction behaviour of Australian magnetite ore in advanced ironmaking with low emission of greenhouse and hazardous substances. Efficient utilisation of magnetite ore which economic demonstrated resources constitute 9.5 gigatonnes will be of high importance to Australian industry and prosperity.
Innovation for anchorage wedge manufacturing. The consumption of tendon anchorage wedges worldwide is in the billions every year, but their manufacturing process is inadequate. The revolutionary technology to be developed by this proposed research will enable the manufacturers to achieve a cost-effective eco-fabrication with minimal material and energy wastages.
NOVEL THERAPEUTICS FOR AUTOIMMUNE DISEASE USING MOUSE SCREENING MODELS. The project aims to use experimental models of human autoimmune disease in the mouse for the testing of developmental isoflavonoid compounds produced by the Industry Partner, for protective effects against autoimmunity. The murine models proposed will duplicate human autoimmune cardiomyopathy, systemic lupus erythematosus and multiple sclerosis, encompassing both organ-specific and systemic autoimmune diseases. Isoflavonoi ....NOVEL THERAPEUTICS FOR AUTOIMMUNE DISEASE USING MOUSE SCREENING MODELS. The project aims to use experimental models of human autoimmune disease in the mouse for the testing of developmental isoflavonoid compounds produced by the Industry Partner, for protective effects against autoimmunity. The murine models proposed will duplicate human autoimmune cardiomyopathy, systemic lupus erythematosus and multiple sclerosis, encompassing both organ-specific and systemic autoimmune diseases. Isoflavonoid protection is anticipated from the antioxidant, anti-inflammatory and oestrogenic characteristics of these compounds/Read moreRead less
Enhancing Direct Cu Recovery through Increased Gas Processing Understanding. This project aims to investigate mechanisms of copper loss during smelting and find new ways to reduce the loss. Smelting, which produces copper matte product and slag tailings, is an important step of the copper-making process from copper sulphides. The loss of copper to slag can be as high as 12 per cent. The project aims to create new knowledge about copper loss by matte droplets floated with gas bubbles generated by ....Enhancing Direct Cu Recovery through Increased Gas Processing Understanding. This project aims to investigate mechanisms of copper loss during smelting and find new ways to reduce the loss. Smelting, which produces copper matte product and slag tailings, is an important step of the copper-making process from copper sulphides. The loss of copper to slag can be as high as 12 per cent. The project aims to create new knowledge about copper loss by matte droplets floated with gas bubbles generated by chemical reactions to the slag phase. The outcomes are intended to enable copper smelters to maximise direct copper recovery, reduce copper production costs and increase the productivity of the smelting process.Read moreRead less
The use of non-traditional materials in production of manganese alloys with economic and environmental benefits. The use of ironstone and siliceous manganese ore in production of silicomanganese will have technological, economic and environmental benefit through improved technology and the use of local materials. It will also stimulate the development of the Tasmanian mineral industry, infrastructure and improvement of employment.
The Design of New Integrase Inhibitors Targeting HIV-1. There is still no cure in sight for the worldwide HIV pandemic and the worsening viral resistance problem creates a need to find new and novel compounds for therapeutic use. This project aims to design and synthesize new anti-HIV drugs by targeting two separate enzymes within the HIV life-cycle. This 'dual-action' approach of designing a single molecular scaffold to target separate enzymes would enable a synergistic effect while minimizing ....The Design of New Integrase Inhibitors Targeting HIV-1. There is still no cure in sight for the worldwide HIV pandemic and the worsening viral resistance problem creates a need to find new and novel compounds for therapeutic use. This project aims to design and synthesize new anti-HIV drugs by targeting two separate enzymes within the HIV life-cycle. This 'dual-action' approach of designing a single molecular scaffold to target separate enzymes would enable a synergistic effect while minimizing development costs. The expected outcomes from this medicinal chemistry project include the discovery of new compounds with the potential for further development as therapeutic agents against HIV.Read moreRead less
Decrease of environmental impact of steelmaking: development of fluorine-free mould flux for steel continuous casting. Sustainable development of the steelmaking industry requires addressing environmental issues, of which reducing fluorine emission in steel continuous casting is one of the most challenging. The aim of this project is the development of fluorine-free mould flux and establishment of the feasibility of the use of this flux in industrial steel casting.
Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric ....Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric oxide regulates large artery stiffness and we believe that other endothelial mediators are also important regulators. Therefore, we aim to explore this in a series of studies. Regulation of stiffness of large arteries will improve treatment of age-related cardiovascular disease (eg isolated systolic hypertension)Read moreRead less