Circular RNAs As Genome Destabilisers In Human Disease
Funder
National Health and Medical Research Council
Funding Amount
$2,163,220.00
Summary
Mutation of genes are hallmarks of both cancer and neurological disorders. My research group has identified roles for circular RNAs in both these processes. Now, we must close the loop by investigating the mechanism of these processes. This will inform not only why these genes are commonly mutated, but by exploiting the highly stable circular RNAs they may provide early prognostic/diagnostic biomarkers and even represent novel therapeutic targets for cancer and Huntington’s disease.
AI-driven Effective Query Formulation for Better Systematic Reviews. This project aims to develop novel AI-based search engine methods to make the creation of systematic reviews cheaper, faster and unbiased. Systematic reviews are the cornerstone for evidence-based decisions in clinical practice and government policy making. Given the pace new research is published at, it is unsustainable to manually conduct systematic reviews in the traditional manner, taking on average 2 years and $350K and be ....AI-driven Effective Query Formulation for Better Systematic Reviews. This project aims to develop novel AI-based search engine methods to make the creation of systematic reviews cheaper, faster and unbiased. Systematic reviews are the cornerstone for evidence-based decisions in clinical practice and government policy making. Given the pace new research is published at, it is unsustainable to manually conduct systematic reviews in the traditional manner, taking on average 2 years and $350K and becoming already outdated when published. The outcomes of this project will lead to systematic reviews of higher quality, while reducing their financial and temporal costs, providing significant benefits to organisations performing reviews and their funders, and to people impacted by decisions made from the reviews.Read moreRead less
Privacy preserving and data utility in outsourced systems. Making the best tradeoff between data privacy and utility is a vital challenge in privacy-preserving outsourcing environments. This project aims to develop a balanced distributed framework to achieve the best utility of outsourced data while protecting private information. The framework consists of general structure of distributed evolutionary algorithms and a predefined topology for high optimization efficiency and a dynamic groupin ....Privacy preserving and data utility in outsourced systems. Making the best tradeoff between data privacy and utility is a vital challenge in privacy-preserving outsourcing environments. This project aims to develop a balanced distributed framework to achieve the best utility of outsourced data while protecting private information. The framework consists of general structure of distributed evolutionary algorithms and a predefined topology for high optimization efficiency and a dynamic grouping recombination model. The project outcomes will be beneficial to applications in the nation as it incorporates new privacy constraints and utility requirements raised by emerging technologies to enable better protection of sensitive information and maximal data utility in outsourced systems. Read moreRead less
Finding answers for complex questions. This project aims to develop a new search paradigm for on-line search engines that presents users with answers to complex questions, rather than forcing them to find answers themselves from lists of retrieved documents. The project will develop a taxonomy of complex answer search tasks, devise novel techniques to increase the effectiveness of complex answer retrieval through interaction and, create a new evaluation framework for precise measurement of syste ....Finding answers for complex questions. This project aims to develop a new search paradigm for on-line search engines that presents users with answers to complex questions, rather than forcing them to find answers themselves from lists of retrieved documents. The project will develop a taxonomy of complex answer search tasks, devise novel techniques to increase the effectiveness of complex answer retrieval through interaction and, create a new evaluation framework for precise measurement of system effectiveness. This project should provide significant advances that will benefit all users of search engines.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100064
Funder
Australian Research Council
Funding Amount
$422,022.00
Summary
Fair and Transparent Information Access in Spoken Conversational Assistants. This project aims to investigate how rich information needed to answer complex questions can be delivered via a speech-only communication channel. Using laboratory user studies, where users can interact with a smart speaker to ask for information about controversial or multi-perspective topics, the project expects to advance knowledge on how to expose pertinent information without creating or reinforcing biases. Expecte ....Fair and Transparent Information Access in Spoken Conversational Assistants. This project aims to investigate how rich information needed to answer complex questions can be delivered via a speech-only communication channel. Using laboratory user studies, where users can interact with a smart speaker to ask for information about controversial or multi-perspective topics, the project expects to advance knowledge on how to expose pertinent information without creating or reinforcing biases. Expected outcomes include novel presentation strategies to access rich information via audio in a fair manner. This should significantly benefit the visually impaired and low-literacy communities by enhancing their access to topics with multiple point of views, which would impact decision making such as who to vote for in elections.Read moreRead less
A data driven paradigm for service-oriented system engineering. This project aims to design and develop a data driven paradigm for service-oriented system engineering that allows system engineers and domain experts in different domains to build software systems easily in order to enable fast technology transfer within and across domain boundaries. This model integrates and automates a suite of efficient approaches for system structure determination, validation and recommendation based on keyword ....A data driven paradigm for service-oriented system engineering. This project aims to design and develop a data driven paradigm for service-oriented system engineering that allows system engineers and domain experts in different domains to build software systems easily in order to enable fast technology transfer within and across domain boundaries. This model integrates and automates a suite of efficient approaches for system structure determination, validation and recommendation based on keyword search, subgraph isomorphism and substructure query techniques. This project is expected to significantly accelerate the application of new technologies, for example, big data analytics and Internet of Things, in many of Australia's critical domains such as e-Health, smart cities, and cybersecurity.Read moreRead less
New approaches to interactive sessional search for complex tasks. This project aims to develop new tools and techniques to improve the accuracy and speed of search and data analytics for complex information tasks. There are currently no publicly available search engines which support users engaged in complex interactive search, or that allow searchers to fully control their own data and privacy. Fundamental research advances, based on understanding real user behaviour and search needs will have ....New approaches to interactive sessional search for complex tasks. This project aims to develop new tools and techniques to improve the accuracy and speed of search and data analytics for complex information tasks. There are currently no publicly available search engines which support users engaged in complex interactive search, or that allow searchers to fully control their own data and privacy. Fundamental research advances, based on understanding real user behaviour and search needs will have an impact on important academic, industrial, and government domains, including virtual assistants, health care (clinical decision support), precision medicine, eDiscovery, crime prevention, and detailed socio-economic evaluations.Read moreRead less
Developing an effective defence to cyber-reputation manipulation attacks. This project will develop new technologies for businesses to accurately identify fake internet reviews. Fake reviews, paid for and/or written with malicious intent, can cause irreparable damage to businesses resulting in revenue loss, consumer dissatisfaction or even closure of businesses. However they are difficult to identify, as they continuously evolve to avoid detection and the volume of Internet reviews makes analysi ....Developing an effective defence to cyber-reputation manipulation attacks. This project will develop new technologies for businesses to accurately identify fake internet reviews. Fake reviews, paid for and/or written with malicious intent, can cause irreparable damage to businesses resulting in revenue loss, consumer dissatisfaction or even closure of businesses. However they are difficult to identify, as they continuously evolve to avoid detection and the volume of Internet reviews makes analysis a monumental task. This project will provide advanced tools to detect fake website reviews and a cybersecurity system prototype ready to be used by industry, making Australia a leader in this field and resulting in a safer internet environment for all.Read moreRead less
Efficient Compression and Querying Techniques for Massive Text Collections. Web search services have become a fundamental tool used by governments, businesses, and individuals, and play a key role in our access to knowledge and information. In this project we aim to develop new techniques for representing the indexes at the heart of web search services, and to devise new processing algorithms with reduced resource requirements for resolving queries and providing useful and topical answers. Hig ....Efficient Compression and Querying Techniques for Massive Text Collections. Web search services have become a fundamental tool used by governments, businesses, and individuals, and play a key role in our access to knowledge and information. In this project we aim to develop new techniques for representing the indexes at the heart of web search services, and to devise new processing algorithms with reduced resource requirements for resolving queries and providing useful and topical answers. Higher query throughput and reduced storage load will benefit providers though reduced hardware and electricity costs, and will benefit society through better access to information, enhanced opportunities to connect and collaborate, and greater long-term scalability as on-line resources continue to multiply.Read moreRead less
New digital deep-time exploration tools for a low-emissions economy. Demand for critical minerals will soar as renewable energy generation increases, but exploration companies currently cannot take full advantage of available exploration data in an Earth evolution context. This project will generate new knowledge in big and complex geodata analysis using an innovative data mining approach. It will enable Lithodat, a small enterprise, to perform cloud-based plate tectonic reconstruction, visualis ....New digital deep-time exploration tools for a low-emissions economy. Demand for critical minerals will soar as renewable energy generation increases, but exploration companies currently cannot take full advantage of available exploration data in an Earth evolution context. This project will generate new knowledge in big and complex geodata analysis using an innovative data mining approach. It will enable Lithodat, a small enterprise, to perform cloud-based plate tectonic reconstruction, visualisation and spatio-temporal analysis of geodata for resource exploration. The outcomes include an enhanced capacity to generate ore prospectivity maps and an improved understanding of their tectonic, geochemical, and geophysical signatures, benefiting Lithodat and their clients in the search for new mineral deposits.Read moreRead less