Establishing Antenatal Screening Uptake For Fetal Anomalies In The NT And Exploring Indigenous Womens Understanding
Funder
National Health and Medical Research Council
Funding Amount
$9,875.00
Summary
This project aims to investigate the views of Indigenous women, their families and health service providers about antenatal screening tests for abnormalities like Down syndrome. This will contribute knowledge about why there is low uptake of screening amongst Indigenous women, and whether changes in the provision of antenatal care are required. This is important because all women, regardless of their culture or location, should be offered the same opportunities and care during pregnancy.
Antenatal Screening For Fetal Anomalies In Indigenous Women: Views Of Indigenous People And Their Health Care Providers
Funder
National Health and Medical Research Council
Funding Amount
$373,204.00
Summary
This project aims to investigate the views of Indigenous women, their families and health service providers about antenatal screening tests for abnormalities like Down syndrome. This will contribute knowledge about why there is low uptake of screening amongst Indigenous women, and whether changes in the provision of antenatal care are required. This is important because all women, regardless of their culture or location, should be offered the same opportunities and care during pregnancy.
A NESTED CASE CONTROL STUDY EVALUATING THE ASSOCIATION BETWEEN THE FACTOR V LEIDEN GENOTYPE AND ADVERSE PREGANCY OUTCOME
Funder
National Health and Medical Research Council
Funding Amount
$165,990.00
Summary
The factor V Leiden gene mutation is present in 1 in 20 of the general population. Recent studies suggest an association between the factor V Leiden gene mutation and adverse pregnancy outcomes. It is currently recommended that women with a history of recurrent pregnancy loss, including a second or third trimester intrauterine death should be screened for the factor V Leiden mutation. Controlled trials are currently underway assessing efficacy of treatment with anticoagulaton therapy for women w ....The factor V Leiden gene mutation is present in 1 in 20 of the general population. Recent studies suggest an association between the factor V Leiden gene mutation and adverse pregnancy outcomes. It is currently recommended that women with a history of recurrent pregnancy loss, including a second or third trimester intrauterine death should be screened for the factor V Leiden mutation. Controlled trials are currently underway assessing efficacy of treatment with anticoagulaton therapy for women who screen positive. However, population screening is currently not recommended because we do not know the significance of a factor V leiden gene mutation for women without a previous history of adverse pregnancy outcome. The question of why some women with a factor V Leiden mutation experience recurrent pregnancy loss whereas other women do not remains unanswered. The primary aim of this study is to determine whether the maternal and- or fetal genotype for factor V Leiden influences the risk of first and second trimester miscarriage within a cohort of 25,000 pregnant women. The aim of further research in this area is to identify a subset of women at increased risk of a second or third trimester fetal loss, based on a combination of genetic, acquired and environmental thrombophilic risk factors, who may benefit from prophylactic treatment with anticoagulation therapy.Read moreRead less
Infrared Spectroscopic Imaging In The Diagnosis Of Cervical Cancer
Funder
National Health and Medical Research Council
Funding Amount
$291,600.00
Summary
In Victoria alone around 500000 Pap smears a year are examined for evidence of cancer of the cervix or conditions that may lead to cancer. This is a time consuming, labour intensive and costly process with a relatively high failure rate. A number of alternative techniques have been explored in the last decade with a view to providing a diagnostic technique that is free of human error, more reliable than the Pap method and easily used. An alternative technique based on using infrared light to pro ....In Victoria alone around 500000 Pap smears a year are examined for evidence of cancer of the cervix or conditions that may lead to cancer. This is a time consuming, labour intensive and costly process with a relatively high failure rate. A number of alternative techniques have been explored in the last decade with a view to providing a diagnostic technique that is free of human error, more reliable than the Pap method and easily used. An alternative technique based on using infrared light to probe smears shows promise in providing such an easily automated reliable method. We, and others have spent a number of years exploring this technique and have solved a number of the problems associated with it. Based on our work in the field and the work of others we now wish to develop a methodology using an infrared micro-imaging spectrometer combined with multivariate statistics that can be used to diagnose cervical cancer and the conditions that lead to cervical cancer.Read moreRead less