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We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Mechanisms And Therapies In Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$8,360,700.00
Summary
Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting ....Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting new knowledge through integrated research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100045
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Coherent Laser Links for Space Applications. Coherent laser links for space applications:
This project seeks equipment to establish a deployable, free-space, coherent laser link to enable Australia’s continued leadership and involvement in large-scale international space projects. It would support optical free-space frequency transfer to expand the capability of the European Space Agency’s Atomic Clock Ensemble in Space mission; tests to validate the inter-satellite interferometry acquisition s ....Coherent Laser Links for Space Applications. Coherent laser links for space applications:
This project seeks equipment to establish a deployable, free-space, coherent laser link to enable Australia’s continued leadership and involvement in large-scale international space projects. It would support optical free-space frequency transfer to expand the capability of the European Space Agency’s Atomic Clock Ensemble in Space mission; tests to validate the inter-satellite interferometry acquisition system for the NASA Gravity Recovery and Climate Experiment follow-on mission; and test-bed development for advanced coherent optical communications systems. Coherent, free-space laser links are an emerging technology for a range of high-impact research fields. The project would enable research relying on precision measurements of time and frequency; advanced inter-satellite laser interferometry, and coherent free-space optical communications. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100062
Funder
Australian Research Council
Funding Amount
$240,000.00
Summary
Universal Optical Transmitter for rapid prototyping and system emulation. Universal optical transmitter for rapid prototyping and system emulation: This Project proposes an integrated, multi-user facility for the generation of extremely wide-bandwidth optical communication signals that will help to dramatically improve the data-handling capability of optical fibres and improve the energy efficiency of optical communication networks. The project will modulate the input of an advanced optical tran ....Universal Optical Transmitter for rapid prototyping and system emulation. Universal optical transmitter for rapid prototyping and system emulation: This Project proposes an integrated, multi-user facility for the generation of extremely wide-bandwidth optical communication signals that will help to dramatically improve the data-handling capability of optical fibres and improve the energy efficiency of optical communication networks. The project will modulate the input of an advanced optical transmitter with multi-level, multi-phase signals at multi-Gb/s rates to generate 'higher-order' modulation formats at multi- terra bits per second rates including orthogonal frequency-division multiplexing (OFDM), Nyquist-wavelength-division multiplexing (WDM), regular WDM and Optical Time-Division Multiplexing (OTDM). With this transmitter the project will investigate advanced optical communications concepts including 'constellations' of phase and intensity, limitations of nonlinearity in optical fibres, signal regeneration, and all-optical routing.Read moreRead less
Creating a national time and frequency network for Australia. This project will develop the means to distribute accurate time and frequency across the Australian continent via an optical fibre network. This network will meet the needs of future telecommunications, science and astronomy projects including the Australian bid for the Square Kilometre Array radio-astronomy project.
Novel Insights Into The Mechanisms Of How Viruses Cause Arthritis-arthralgia
Funder
National Health and Medical Research Council
Funding Amount
$626,459.00
Summary
Many viruses are known to cause arthritis (e.g. HIV, hepatitis viruses, mosquito borne viruses). Symptoms of viral arthritis include joint pain, stiffness, and swelling. The mechanism of disease is poorly understood. We have developed a novel animal model of disease by which to study arthritic disease caused by viral infections. This model provides an excellent opportunity to explore the mechanisms of rheumatic disease in a complete functioning animal and to explore new treatment regimes.