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Role Of Microvascular Flowmotion In Skeletal Muscle Glucose Metabolism
Funder
National Health and Medical Research Council
Funding Amount
$596,971.00
Summary
Obesity and type 2 diabetes are nationally and globally reaching epidemic rates. This project investigates the regulation of blood flow within muscle and its impact on metabolism. Outcomes from the study may lead to diagnostic tools and treatments for cardiovascular disease associated with obesity, hypertension and type 2 diabetes.
Physiological Mechanisms Of Experimental Preeclampsia.
Funder
National Health and Medical Research Council
Funding Amount
$471,862.00
Summary
Defining the sequence of abnormalities of immune system regulation and vascular reactivity would greatly enhance our understanding of the underlying mechanisms of preeclampsia (hypertension in pregnancy) and lead to opportunities for definitive treatment for the mother and baby other than by urgent delivery of the pregnancy. Results from this study may lead to tests in early pregnancy of the hypoxic environment such as cytokine imbalance.
An Integrated Approach To Inotropic Support In Preterm Neonates
Funder
National Health and Medical Research Council
Funding Amount
$694,449.00
Summary
Poor cardiovascular function in preterm babies can lead to inadequate blood flow to the brain and brain injury. Current treatments to improve heart function are often ineffective. This study will examine the effects of treatment on different parts of the cardiovascular system, and how these effects interact. It will identify reasons for the lack of effectiveness and provide insight which will help to design better treatments for preterm babies.
In What Position Should We Be Sleeping Preterm Infants In The NICU?
Funder
National Health and Medical Research Council
Funding Amount
$409,742.00
Summary
Preterm babies are at risk of brain injury caused by low cerebral blood flow and oxygenation. The prone sleeping position (lying on abdomen) has been found to decrease both cerebral oxygenation and blood pressure in healthy term babies, and is a major risk factor for Sudden Infant Death Syndrome. However, it is common practice for preterm babies to be slept in the prone position.This study will examine the effects of prone vs supine positions on brain oxygenation in the preterm babies.
The Effects Of Tonic Muscle Pain On The Sympathetic And Somatic Motor Systems In Human Subjects
Funder
National Health and Medical Research Council
Funding Amount
$462,948.00
Summary
The main objective of this proposal is to reveal the effects of nociceptive reflexes in humans, and thus identify their functional and clinical implications. By performing invasive recordings from the nerves that control blood vessels and muscles in healthy volunteers subjected to long-lasting (~1 hour) experimental pain, this work will increase our understanding of the adaptive changes that pain induces and improve treatments to prevent pain from becoming chronic.
Neuro-protection In The Preterm Brain - A New Role For Dopamine Therapy?
Funder
National Health and Medical Research Council
Funding Amount
$540,347.00
Summary
Brain injury in premature babies leads to long term adverse outcome. Preliminary data show that dopamine improves brain oxygen. Our study will define effects of dopamine in preventing injury in the immature brain, using animal studies. In immature lambs receiving dopamine, we will test the protective effect of dopamine on brain oxygenation during hypoxia. Outcome will be measured by examining cell injury on lamb brain slices.
Building Tissue Engineered Flaps For Surgical Reconstruction
Funder
National Health and Medical Research Council
Funding Amount
$548,453.00
Summary
As a result of serious trauma, burns or cancer surgery, large areas of new skin may be required. Of the three major skin layers - epidermal and dermal replacements are available clinically, but the third layer - the underlying fat tissue layer is yet to be developed. This project has devised a novel product to rapidly recreate the skin fat layer and additionally rapidly grow new blood vessels in these layers which will enable excellent skin coverage in all forms of major skin loss.
Understanding The Physiological Advantage Behind Delayed Cord Clamping.
Funder
National Health and Medical Research Council
Funding Amount
$647,539.00
Summary
Surviving the transition to newborn life at birth is critically dependent upon a major re-organization of the infant’s circulation which is triggered by umbilical cord occlusion and the onset of air-breathing. This application is focused on investigating procedures that assist in stabilising the circulation during the newborn period and protect it from large swings in cardiac output and blood flow that have the potential to cause vascular-related injury in newborn infants.
A Pre-clinical Trial Of Early Blood Transfusion For Improving Cerebral Oxygen Delivery In Very Preterm Neonates
Funder
National Health and Medical Research Council
Funding Amount
$970,603.00
Summary
Long-term disability is common in babies born prematurely. This may be due to insufficient delivery of oxygen to the brain, but currently there is no treatment that increases oxygen delivery to the brain. We will determine if blood transfusion is more effective than current treatments given to prevent brain injury in preterm babies. Transfusion has two benefits. It will increase the amount of blood going to the brain. It will also increase the amount of oxygen carried by the blood.
RZR-alpha In The Control Of Proliferative Vascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$521,706.00
Summary
Four million Australians have cardiovascular disease accounting for 35% of all deaths. CVD is the most expensive disease burden and a National Health Priority. Smooth muscle cell growth is a cause of CVD. However, the mechanisms controlling SMC hyperplasia are poorly understood. This project will provide key insights on the role of RZR-alpha in the pathogenesis of blood vessel disease, and develop novel gene-targeting approaches for new opportunities to control complications of CVD.