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The Role Of CCR6 In IL-17-producing CD8+ T Lymphocyte Activation And Trafficking
Funder
National Health and Medical Research Council
Funding Amount
$514,041.00
Summary
T lymphocytes play an important role in the control of infection, but can also contribute to diseases such as autoimmune disease and cancer. This research will identify the function of a new subtype of T lymphocyte and determine whether inhibiting its function prevents disease.
Control Of T Helper Cells In Autoimmunity And Anti-tumour Responses.
Funder
National Health and Medical Research Council
Funding Amount
$434,953.00
Summary
The proposed studies aim to improve our understanding of the factors that regulate a specialised immune cell type called “T helper” cells and their function in models of autoimmune disease and during anti-tumour immune responses. The project will investigate (1) the role of a signalling protein called Interleukin 27 in these processes and (2) how several novel genes, recently found to be associated with the development of MS in humans, influence T helper cell activity.