Tackling Antimicrobial Resistance In Neonatal Sepsis: Australia And Beyond
Funder
National Health and Medical Research Council
Funding Amount
$566,164.00
Summary
This project aims to establish clear data regarding the burden of antibiotic resistance in neonates in Australia & in our local South East Asian region. This will be achieved by establishing systematic data collection for infections with multi-resistant bacteria in Australian neonatal intensive care units, reviewing published literature regarding the cause of infections in South East Asian neonates, and continuing collaborative work to establish a new treatment regimen for neonatal sepsis.
Leveraging The Interface Between Epidemiology And Molecular Biology To Enhance Disease Prevention
Funder
National Health and Medical Research Council
Funding Amount
$1,850,925.00
Summary
Some diseases are becoming more common over time.The increase over time is too rapid to be due to genetics alone. My research program aims to identify the environmental drivers of these diseases so that we can improve the current efforts to stop these diseases before they even begin. The research program has a focus on factors impacting on how a child's brain develops, how food allergy begins and the factors that can prevent multiple sclerosis onset or slow progression.
Revolutionising Multiple Sclerosis Care And Trials Through E-health
Funder
National Health and Medical Research Council
Funding Amount
$2,182,124.00
Summary
Multiple Sclerosis (MS) is now a highly treatable disease. However, many people with MS are not treated optimally because health care delivery is intermittent and disease monitoring is patchy. People failing treatment should switch quickly to prevent disability, but the treatment choices and sequences also need to be safe long-term. The solution to these problems, to be validated by my team, is greater involvement of people with MS in their own monitoring though e-health tools.
This program directly addresses the major threat of antimicrobial resistance , bringing together the power of modern genomics and the promise of novel positive therapies to eradicate AMR organisms and AMR genes from individuals at risk from severe infection.
Overcoming The Barriers To Treatment Of Multi-drug Resistant Gram-negative Bloodstream Infections In Australian Children
Funder
National Health and Medical Research Council
Funding Amount
$447,603.00
Summary
There is a critical need to develop new treatments for children with antibiotic resistant infections. The most important bacteria causing resistant infections are known as Gram-negative bacteria. Doctors treating children with resistant Gram-negative infections are faced with few antibiotic options. This project will discover the most important resistant infections in Australian children, and trial a new antibiotic to help doctors to use it in the right children and at the right dose.
Over the next 5 years my team and I plan to study parasite invasion and blood cell enslavement to guide the design of better vaccines and medicines. Malaria as a deadly parasitic disease caused by large-scale infection of the body’s red blood cells. To design more effective vaccines and improved drugs to globally eliminate malaria we need to improve our understanding of how parasites infect and enslave our blood cells so they can grow rapidly and avoid our immune system.