A Multi-protein Vaccine Targeting The Oral Pathogens Associated With Chronic Periodontitis
Funder
National Health and Medical Research Council
Funding Amount
$717,692.00
Summary
Periodontitis is a chronic inflammatory disease associated with specific bacteria leading to the destruction of the toothÍs supporting tissues and ultimately tooth loss and is a major public health problem in all societies. Our research is focused on designing a vaccine that targets the major bacteria associated with periodontitis. We aim to produce a triple antigen vaccine and investigate the applicability of a vaccine administered under the tongue as an alternative to needle injections.
Defining The Role Of Innate T Cells In The Onset And Progression Of Chronic Periodontitis
Funder
National Health and Medical Research Council
Funding Amount
$581,978.00
Summary
Particular immune cell populations (innate T cells), have a critical role in immunity. These cells are stimulated by bacterial cell wall components and are one of the first cells to appear after infection. We have shown that these innate T cells are stimulated by oral bacteria that cause the disease chronic periodontitis. This project will investigate how these innate T cells affect bacterial induced periodontitis and what role they play in disease outcomes.