Mucosal Human Immunodeficiency Virus Vaccine Late Pre-clinical Evaluation
Funder
National Health and Medical Research Council
Funding Amount
$575,315.00
Summary
Despite many candidate vaccines entering clinical development for protection against HIV, none has yet been successful. This proposal centres on late preclinical development for a novel mucosal vaccine strategy for HIV, which combines a preclinically-proven approach to generating strong T cell immune responses, with an existing approach to generating broadly neutralising antibody responses to HIV. Proof of synergy between these approaches will lead directly to clinical development.
Targeting Collagen Cross-linking To Improve Scar Appearance
Funder
National Health and Medical Research Council
Funding Amount
$873,305.00
Summary
Scarring is a significant problem after injury, and the life-long appearance of scar can be very detrimental to peoples’ wellbeing, both psychological and physical. This work will develop a new drug to improve scar appearance. The drug is likely to be effective even after scar has formed, making it possible to improve scarring in many people. This will improve the quality of life for people after injury.
A Novel Strategy To Enhance T Cell-mediated Immunity To Vaccine Antigens
Funder
National Health and Medical Research Council
Funding Amount
$234,592.00
Summary
Globally there are about 33 million people living with HIV. The disease has already resulted in 23 million deaths and 2.5 million people are newly infected each year. Similarly, TB kills nearly 2 million people every year and infects about 1% of the worldÍs population every year. A vaccine is the best and also likely the only long-term solution for HIV/TB disease prevention. This research proposal looks at novel strategies to increase the efficacy of vaccines for diseases such as HIV/TB.
This proposal seeks to develop a novel non-invasive method of measuring intra-cranial pressure, an important diagnostic parameter in many form of brain injury or neural disease. It works by quantitative video analysis of the pulsation of the major vein in the eye during induced rises in eye pressure. Many years of study by our group have determined the relationship between vein pulsation pressure and intra-cranial pressure, and this information is used to produce an accurate measurement of intra ....This proposal seeks to develop a novel non-invasive method of measuring intra-cranial pressure, an important diagnostic parameter in many form of brain injury or neural disease. It works by quantitative video analysis of the pulsation of the major vein in the eye during induced rises in eye pressure. Many years of study by our group have determined the relationship between vein pulsation pressure and intra-cranial pressure, and this information is used to produce an accurate measurement of intra-cranial pressure without the need for surgery.Read moreRead less
Application Of Sutureless Technology 'SurgiLux' For Dura Mater Repair: A Proof Of Concept Study
Funder
National Health and Medical Research Council
Funding Amount
$213,125.00
Summary
A unique technology that combines biomaterials and lasers to effectively close and seal wounds could replace sutures in delicate surgery close to the brain. Wound closure in the cranium is still reliant upon sutures or 'stitches' and these have complications; a major one being leakage of cerebro spinal fluid (CSF). The application of 'SurgiLux' technology will both close and seal these wounds quickly and easily, with significant health and economic benefits.
Developing A Prototype Of A Next Generation Brain Computer Interface
Funder
National Health and Medical Research Council
Funding Amount
$837,398.00
Summary
Persons affected by quadriplegia and hemiplegia from stroke and spinal cord injury have few treatment options. Brain Machine Interfaces reconnect brain to a prosthetic limb, bypassing damaged nervous system. Our group has developed a BMI that can be implanted minimally-invasively, inside a blood vessel in the brain. We propose to manufacture a world-first device for a human clinical trial pilot study. The aim is to restore mechanical control over the physical environment for a paralysed patient.
Interactive Attention Training Technology To Enhance Cognitive Skills In Early Life
Funder
National Health and Medical Research Council
Funding Amount
$759,680.00
Summary
Over 30,000 Australian children enter school with attention difficulties each year. We have established a suite of tasks to train attention based on over 20 years of research into neurodevelopmental disorders and attention. These are delivered on tablets in the form of a game known as TALI Train. We now aim to show TALI can improve attention in children with acquired brain injuries and typically developing children for commercialisation to a broad market.