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An Australasian, Multi-centre, Randomized, Double-blind, Placebo-controlled Trial Of The Efficacy Of Fluoxetine In Improving Functional Recovery After Acute Stroke
Funder
National Health and Medical Research Council
Funding Amount
$2,306,367.00
Summary
Stroke is one of the top three causes of disability. Treatments that improve recovery after stroke are lacking. We reviewed the world literature and found a number of very small studies which, together, suggest that the antidepressant drug, fluoxetine, may improve the recovery in stroke patients. AFFINITY is a large trial in 1600 Australians and New Zealanders with stroke which aims to find out whether taking fluoxetine for 6 months after a stroke improves recovery compared to a placebo.
Motor coordination in infancy and its relationship to motor and psychosocial development in childhood. Few studies have examined the impact of early motor development on later development, even though there is evidence to show that these early movements influence later motor ability. Motor development can also impact on cognitive, emotional and social development. The current study has data on early motor ability in over 90 infants which includes children at risk of developmental disorders. We ....Motor coordination in infancy and its relationship to motor and psychosocial development in childhood. Few studies have examined the impact of early motor development on later development, even though there is evidence to show that these early movements influence later motor ability. Motor development can also impact on cognitive, emotional and social development. The current study has data on early motor ability in over 90 infants which includes children at risk of developmental disorders. We will carry out a longitudinal investigation of the relationship between early motor development in infancy on motor and psychosocial development in childhood. The results will provide information on early markers for developmental disorders and appropriate intervention techniques than can be initiated in infancy. Read moreRead less
Revealing the beneficial effects of acoustic stimulation on the human brain. This project aims to provide greater understanding of the neural mechanisms by which initiation of motor responses can be improved by unexpected auditory stimulation. Initiating motor actions appears natural and effortless, but is underpinned by complex neural mechanisms that are not well understood. Using novel brain stimulation techniques, the project aims to assess the potential for properly timed strong sensory stim ....Revealing the beneficial effects of acoustic stimulation on the human brain. This project aims to provide greater understanding of the neural mechanisms by which initiation of motor responses can be improved by unexpected auditory stimulation. Initiating motor actions appears natural and effortless, but is underpinned by complex neural mechanisms that are not well understood. Using novel brain stimulation techniques, the project aims to assess the potential for properly timed strong sensory stimulation during movement preparation to induce neural plasticity and motor learning. This knowledge would have important implications across a number of fields, including neuroscience, sports science, and applied ergonomics.Read moreRead less
The genetic and diagnostic relationship between motor control and Attention Deficit Hyperactivity Disorder. Children with Attention Deficit Hyperactivity Disorder (ADHD) often have comorbid Developmental Coordination Disorder (DCD). This project will utilise the expertise of leading researchers in Australia and the Netherlands to investigate the genetic and diagnostic relationship between these two disorders utilising a large sample of twins and their siblings. We will examine the neuropsych ....The genetic and diagnostic relationship between motor control and Attention Deficit Hyperactivity Disorder. Children with Attention Deficit Hyperactivity Disorder (ADHD) often have comorbid Developmental Coordination Disorder (DCD). This project will utilise the expertise of leading researchers in Australia and the Netherlands to investigate the genetic and diagnostic relationship between these two disorders utilising a large sample of twins and their siblings. We will examine the neuropsychological functioning in these groups of children in order to gain a better understanding of their genetic relationship. These findings will provide insight into the current DSM-IV classification of these disorders compared with other models used to investigate the relationship between poor motor coordination and ADHD.Read moreRead less
I am a physiotherapist with special expertise in ergonomics. My research aims to improve health outcomes through an understanding the physical impact of new technology use.
How brain oscillations influence our behaviour. This project aims to reveal how sudden, intense stimuli impair or facilitate concurrent actions. Startling sounds can disrupt the execution of movements and distract attention from vital events in the environment, with potential disastrous consequences when handling complex equipment such as airplanes, cars and trucks, or surgical instruments. This project will combine classic experimental and novel neuro-modulatory techniques with the measurement ....How brain oscillations influence our behaviour. This project aims to reveal how sudden, intense stimuli impair or facilitate concurrent actions. Startling sounds can disrupt the execution of movements and distract attention from vital events in the environment, with potential disastrous consequences when handling complex equipment such as airplanes, cars and trucks, or surgical instruments. This project will combine classic experimental and novel neuro-modulatory techniques with the measurement of oscillatory brain activity. Expect outcomes will inform theories of cognitive function and the design of interventions to reduce the negative effects of sudden, distracting events.Read moreRead less