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Urinary continence and incontinence in men: New insight through new technologies. Healthy ageing in men is largely overlooked. Disorders of continence are surprisingly common with increasing age, and are socially debilitating. To understand changes in continence and address healthy ageing it is first necessary to gain an understanding of continence mechanisms in healthy men. Continence in women has received wide attention, but anatomy and function differ, as do the challenges throughout life (ch ....Urinary continence and incontinence in men: New insight through new technologies. Healthy ageing in men is largely overlooked. Disorders of continence are surprisingly common with increasing age, and are socially debilitating. To understand changes in continence and address healthy ageing it is first necessary to gain an understanding of continence mechanisms in healthy men. Continence in women has received wide attention, but anatomy and function differ, as do the challenges throughout life (childbirth vs. prostate disease). Using novel methods we will test a new hypothesis of male continence with the goal to provide new physiological discoveries, new methods, and baseline data upon which strategies to enhance healthy ageing and reduce the economic burden of disorders of continence can be developed and refined. Read moreRead less
An investigation into performance characteristics of elite male and female soccer players in training and competition environments. The aim of the project is to identify critical determinants of soccer performance that will improve preparation of Australian teams for international competition. Three studies are proposed. Study One will utilize a decade of physical performance and anthropometric data on male and female soccer players at the Australian Institute of Sport to identify physical perfo ....An investigation into performance characteristics of elite male and female soccer players in training and competition environments. The aim of the project is to identify critical determinants of soccer performance that will improve preparation of Australian teams for international competition. Three studies are proposed. Study One will utilize a decade of physical performance and anthropometric data on male and female soccer players at the Australian Institute of Sport to identify physical performance standards characteristic of elite players. Study Two will comprise match analyses to delineate crucial physical, technical and tactical aspects of individual and team performance. Study three will identify characteristics specific to elite goalkeepers that may be used for monitoring responses to training and competition.Read moreRead less
A longitudinal study of neuropsychological and neuromotor effects of low level manganese exposure. This study will investigate the neuropsychological and neuromotor effects of low level exposure to mangenese particulate. Previous studies have indicated symptomology of high level exposure, but there is contention in the literature regarding the effects of low levels of exposure. Our aim is to refine measures of cumulative exposure and develop a more comprehensive and senstitive testing protocol t ....A longitudinal study of neuropsychological and neuromotor effects of low level manganese exposure. This study will investigate the neuropsychological and neuromotor effects of low level exposure to mangenese particulate. Previous studies have indicated symptomology of high level exposure, but there is contention in the literature regarding the effects of low levels of exposure. Our aim is to refine measures of cumulative exposure and develop a more comprehensive and senstitive testing protocol than has been reported thus far. These measures and protocols will be incorporated into a longitudinal design, which has not been conducted in research studies to date. In addition, a database of exposure variables will be developed to facilitate long-term, accurate research into the effects of the low levels of exposure.Read moreRead less
Influence of athletic footwear on lower limb biomechanics of pubertal girls. This project aims to determine whether athletic footwear with appropriate design features can help improve neuromuscular control and, in doing so, reduce the potentially deleterious forces on the knee and lower limb structures of pubertal girls. As girls reach puberty, they become less able to control the movement patterns of their lower limbs, particularly in high-demand tasks like running and jumping. Better-designed ....Influence of athletic footwear on lower limb biomechanics of pubertal girls. This project aims to determine whether athletic footwear with appropriate design features can help improve neuromuscular control and, in doing so, reduce the potentially deleterious forces on the knee and lower limb structures of pubertal girls. As girls reach puberty, they become less able to control the movement patterns of their lower limbs, particularly in high-demand tasks like running and jumping. Better-designed footwear for pubertal girls may improve movement patterns, decrease the likelihood of musculoskeletal injury and improve physical activity participation rates. Project outcomes may lead to the development of such footwear, and are also anticipated to expand our understanding of female developmental biomechanics.Read moreRead less
Optimising the spring in your step to enhance footwear design. This project aims to examine how the nervous system adjusts the mechanical function of our feet across a spectrum of speeds, from slow running through to maximal effort sprinting. The proposed research will explore how the nervous system controls the function of the foot to meet the ever-varying demands of locomotion in the real-world. Expected outcomes of this project are to determine if running shoes help or hinder the natural spri ....Optimising the spring in your step to enhance footwear design. This project aims to examine how the nervous system adjusts the mechanical function of our feet across a spectrum of speeds, from slow running through to maximal effort sprinting. The proposed research will explore how the nervous system controls the function of the foot to meet the ever-varying demands of locomotion in the real-world. Expected outcomes of this project are to determine if running shoes help or hinder the natural spring-like function of the foot. It will explain a conceptually novel design allowing shoes to support our feet, whilst harnessing the energetic benefits of the foot's spring-like function. This research has the potential to revolutionise athletic footwear design and has direct implications for enhanced performance in running athletes.Read moreRead less
Athletic footwear for reducing knee loads in girls and women. This project aims to develop a novel athletic shoe that can reduce harmful knee loads during sport in adolescent girls and young women. As girls reach puberty, they become less able to control the movement patterns of their knees and lower limbs - particularly in high-demand tasks like jumping. The project will develop a new ASICS shoe that will be ‘field-tested’ during sporting activity with high ACL injury risk (netball) to evaluate ....Athletic footwear for reducing knee loads in girls and women. This project aims to develop a novel athletic shoe that can reduce harmful knee loads during sport in adolescent girls and young women. As girls reach puberty, they become less able to control the movement patterns of their knees and lower limbs - particularly in high-demand tasks like jumping. The project will develop a new ASICS shoe that will be ‘field-tested’ during sporting activity with high ACL injury risk (netball) to evaluate its effect on tibial shock (in-field surrogate measure of knee load) and player comfort compared to a conventional shoe. Expected outcomes include reduced healthcare costs associated with the treatment of serious knee injury, including surgical reconstruction and early-onset knee osteoarthritis.Read moreRead less
Neuromuscular adaptations to training, cross training and passive physical interventions: A neurophysiological approach to understanding human performance and musculoskeletal injury. The expected national benefit arising from this research is three fold: (i) developing knowledge of approaches taken to improve exercise performance across the spectrum of novice to elite levels of participation, (ii) improved understanding of the physiological basis for widely applied interventions used to facilita ....Neuromuscular adaptations to training, cross training and passive physical interventions: A neurophysiological approach to understanding human performance and musculoskeletal injury. The expected national benefit arising from this research is three fold: (i) developing knowledge of approaches taken to improve exercise performance across the spectrum of novice to elite levels of participation, (ii) improved understanding of the physiological basis for widely applied interventions used to facilitate exercise, performance, as well as injury prevention and rehabilitation, and (iii) increasing the pool of world-class researchers who will make a substantial difference to the health and wellbeing of the community through one post-doctoral and two doctoral programs. This project will cement existing tertiary-industry sector collaboration, which will ensure long-standing benefits to the community.Read moreRead less
Developing new methods to retrieve and analyse preserved genetic information. This project will position Australia at the leading edge of research into preserved DNA, and will use innovative molecular biology approaches to develop a range of new forensic, archaeological and medical applications. It will build Australian knowledge and scientific capacity by developing core expertise and training personnel in areas important for biosecurity, customs and quarantine, forensics/counter-terrorism, and ....Developing new methods to retrieve and analyse preserved genetic information. This project will position Australia at the leading edge of research into preserved DNA, and will use innovative molecular biology approaches to develop a range of new forensic, archaeological and medical applications. It will build Australian knowledge and scientific capacity by developing core expertise and training personnel in areas important for biosecurity, customs and quarantine, forensics/counter-terrorism, and studies of climate change. It will also create and foster research innovation in molecular biology with spin-offs for evolution, archaeology, medical and conservation biology research, and will also encourage involvement with the rapidly expanding field of genomics and bioinformatics.Read moreRead less
Methods to infer dense genomic information from sparsely genotyped populations. Prediction of phenotype based on DNA polymorphisms or sequence has important applications such as prediction of disease risk in human medicine and prediction of genetic value in plant or animal breeding. This project will enhance precision and lower the cost of association studies leading to substantial increase in accuracy of such predictions. This will allow more effective genetic improvement, particularly of diff ....Methods to infer dense genomic information from sparsely genotyped populations. Prediction of phenotype based on DNA polymorphisms or sequence has important applications such as prediction of disease risk in human medicine and prediction of genetic value in plant or animal breeding. This project will enhance precision and lower the cost of association studies leading to substantial increase in accuracy of such predictions. This will allow more effective genetic improvement, particularly of difficult but important traits such as disease resistance, reduced green-house gas emissions and product quality. The same methods can be extended to improve genetic improvement in plants and better prediction of human disease risk. Read moreRead less
Innovative approaches to understanding and limiting the public health risks of Cryptosporidium and Giardia in animals in Australian catchments. Sophisticated molecular typing and modelling will be used to determine if chlorine-resistant parasites in animals in catchments are responsible for infection in humans. Improved catchment management and risk mitigation strategies will be developed during this project, which will make a substantial contribution to the provision of safe drinking water acro ....Innovative approaches to understanding and limiting the public health risks of Cryptosporidium and Giardia in animals in Australian catchments. Sophisticated molecular typing and modelling will be used to determine if chlorine-resistant parasites in animals in catchments are responsible for infection in humans. Improved catchment management and risk mitigation strategies will be developed during this project, which will make a substantial contribution to the provision of safe drinking water across Australia.Read moreRead less