Identifying Risk For Second And Subsequent Pregnancies: A Longitudinal Record Linkage Study
Funder
National Health and Medical Research Council
Funding Amount
$586,129.00
Summary
Interventions (eg. induction of labour) or conditions (eg bleeding) in one pregnancy may affect outcomes in the next pregnancy (eg. risk of complications). These relationships are under-investigated. Using population data on over 194,000 women we can look at repeat pregnancies experienced by individual women. We will use this data to investigate whether interventions in one pregnancy affect subsequent birth outcomes (for mother or baby) and whether particular conditions are likely to recur.
Identification, Validation And Functional Analysis Of Genes And MiRNAs Involved In Recurrent Non-small Cell Lung Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$104,664.00
Summary
Recurrence of lung cancer after treatment affects 20-85% of patients. Current prognostication tools are inaccurate and thus patients receive generic treatments. Our intention is to identify genes involved in recurrence of lung cancer. We foresee that this will translate to earlier identification of at-risk patients enabling individualised less toxic and more successful treatments. We also hope to better understand biology of lung cancer recurrence and discover new targets for treatment.
Sun Exposure, Vitamin D And The Outcome Of Prostate Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$494,698.00
Summary
We will find out whether hours of sun exposure, reported in a standard interview by men with prostate cancer, reduces prostate cancer recurrence and progression. For any effect of sun exposure ithat we observe, we will find out whether it works through vitamin D, which is produced by sunshine on the skin, or is affected by changes in the vitamin D receptor gene, which produces the protein the binds with vitamin D on cells and makes it work. Prostate cancer is the most common cancer in men in Aus ....We will find out whether hours of sun exposure, reported in a standard interview by men with prostate cancer, reduces prostate cancer recurrence and progression. For any effect of sun exposure ithat we observe, we will find out whether it works through vitamin D, which is produced by sunshine on the skin, or is affected by changes in the vitamin D receptor gene, which produces the protein the binds with vitamin D on cells and makes it work. Prostate cancer is the most common cancer in men in Australia, and this study, using two of the largest collections of clinical outcomes data for this disease, will inform researchers, clinicians and consumers about the possible benefits of sun exposure and Vitamin D in the prevention of recurrence or progression of prostate cancer. On present evidence, these effects are very plausible possibilities. It may also identify sub-groups of men in whom sun exposure or vitamin D might be particularly beneficial in improving outcome of prostate cancer.Read moreRead less
POST-OPERATIVE CROHNS DISEASE RECURRENCE: EVALUATION OF AETIOLOGIC FACTORS And AN ALGORITHM And TRIAL TO MODIFY RECURRENCE.
Funder
National Health and Medical Research Council
Funding Amount
$123,472.00
Summary
Eighty percent of patients with Crohn’s disease (CD) need an operation at some stage. The disease invariably returns, and in 70% of patients further surgery is required. This project aims to determine whether particular bacteria cause the disease to recur and will look at the value of antibiotic treatment to prevent severe disease recurring. It will also assess whether adjusting treatment based on changes seen at the operative site during follow-up influences disease recurrence .
Treatment Of Asymptomatic Candidiasis In Pregnant Women For The Prevention Of Preterm Birth: A Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,120,373.00
Summary
Being born too early is a leading cause of perinatal death and morbidity. This trial seeks to determine whether screening for and treating candidiasis in pregnancy reduces the risk of this serious health problem. The trial will discover whether a simple treatment in pregnancy can reduce preterm birth. If positive, the results will be relevant to the management of every pregnancy.
The Extent And Impact Of Pharmaceutical Opioids For Chronic Non-cancer Pain
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
There have been dramatic increases in the use of pharmaceutical opioids (PO) for chronic non-cancer pain (CNCP), despite limited data on their long-term effectiveness and an increase in associated harm. This Fellowship provides critical new data to inform both clinicians and policymakers on the global extent of PO for CNCP, trajectories of problematic use and associated morbidity and a unique evaluation of the impact of real-time prescription monitoring program to reduce these harms.