Persistent Particles And Monocyte/macrophage Function
Funder
National Health and Medical Research Council
Funding Amount
$356,232.00
Summary
The project studies how a type of white blood cell interacts with damaged tissue at a site of inflammation, such as an occluded vessel or a brain plaque, and also with immunological adjuvants. It is believed that the nature of the material to be removed is critical in determining the effect on the white blood cell such that it can stay longer at the site and cause more damage or stimulate more immunity, respectively. The ultimate goal is to understand the cellular biochemistry responsible to hel ....The project studies how a type of white blood cell interacts with damaged tissue at a site of inflammation, such as an occluded vessel or a brain plaque, and also with immunological adjuvants. It is believed that the nature of the material to be removed is critical in determining the effect on the white blood cell such that it can stay longer at the site and cause more damage or stimulate more immunity, respectively. The ultimate goal is to understand the cellular biochemistry responsible to help diseases, such as atherosclerosis and Alzheimer's disease, and to improve the quality of human adjuvants.Read moreRead less
Procoagulant Expression In The Antiphospholipid Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$196,527.00
Summary
This study proposes to investigate how white blood cells contribute to clotting that occurs in patients with an immune disorder called the Antiphospholipid Syndrome. This condition is more common than is generally known, and accounts for about one fifth of clots in the legs and about one third of strokes that occur in young people. It is also a common cause of miscarriages. The study focuses on how activation of the immune system, and inflammation interact to make certain white blood cells expre ....This study proposes to investigate how white blood cells contribute to clotting that occurs in patients with an immune disorder called the Antiphospholipid Syndrome. This condition is more common than is generally known, and accounts for about one fifth of clots in the legs and about one third of strokes that occur in young people. It is also a common cause of miscarriages. The study focuses on how activation of the immune system, and inflammation interact to make certain white blood cells express a molecule called Tissue Factor, which initiates blood clots.Read moreRead less