Harnessing Macrophage-derived Cytokine Signalling In Skeletal Muscle Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$991,926.00
Summary
We propose to develop novel therapies and tissue engineering approaches for the treatment of muscle injury and wasting disorders using specific muscle stem cells called satellite cells. Our ultimate aim is to accelerate the development of safe, effective and affordable muscle stem cell-based therapies, in an attempt to lessen the disease burden of muscle wasting disorders. The approach will make use of the novel stem cell activating compounds and immune cells that we have identified.
Reprogramming Human Fibroblasts Into Induced Trophoblast Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$889,064.00
Summary
We have been able to generate artificial human trophectoderm which is the tissue that creates the placenta. This will allow us to do research in how the genes control the fate of these cells without the need of human embryos or placenta. We anticipate that the derivation and characterising these cells will revolutionise placenta research, which in turn will contribute to the establishment of new therapies for placenta disease and infertility.
Exploring Non-canonical Roles For The Ribosomal RNA Genes Critical For Malignant Transformation And Cell Fate
Funder
National Health and Medical Research Council
Funding Amount
$1,972,669.00
Summary
Genes are encoded by linear DNA sequences, and whether they are expressed or silenced will depend on modifications and 3D interactions with other genomic regions. We aim to identify genes that interact with the a subnuclear body called the nucleolus during cancer development and differentiation. Understanding how these 3D genomic interactions are altered for the coordinated expression of a suite of genes may provide the basis for novel strategies to manipulate gene expression in disease.