Humanisation And Pre-clinical Validation Of A Therapeutic Anti-cancer Antibody
Funder
National Health and Medical Research Council
Funding Amount
$699,136.00
Summary
This grant will develop a novel antibody against a protease expressed on cancer cells. Preclinical studies, and antibody humanisation, will be performed. This project will also provide vital information on optimal therapeutic approaches with the antibody that can be ultimately taken into human trials.
ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.
Defining Epigenetic Predictors Of Long-term Outcomes Of Preterm Birth
Funder
National Health and Medical Research Council
Funding Amount
$409,408.00
Summary
On average, those born premature do worse health-wise than those born at term. However, some do worse than others. Our aim is to identify these people at birth to better help doctors and parents to closely monitor their health. For this, we will be “reading the diary of pregnancy” in the molecules added to chromosomes in blood during pregnancy in young adults with will characterised states of health. We will analyse DNA from blood that we will extract from stored heel prick spots.
Electroweak phase transition: A cosmological window to new particle physics. The observed asymmetry between matter and antimatter in the visible universe arguably represents the major challenge to contemporary particle physics and cosmology. This project explores new theoretical, phenomenological and computational aspects of the electroweak phase transition and the generation of the cosmic matter-antimatter asymmetry in the early universe together with their links to new physics that may manifes ....Electroweak phase transition: A cosmological window to new particle physics. The observed asymmetry between matter and antimatter in the visible universe arguably represents the major challenge to contemporary particle physics and cosmology. This project explores new theoretical, phenomenological and computational aspects of the electroweak phase transition and the generation of the cosmic matter-antimatter asymmetry in the early universe together with their links to new physics that may manifest at present and future high-energy colliders and gravitational wave observatories. Read moreRead less
New Physics and the quark/lepton family replication puzzle. This project aims to investigate how new physics impacts on the puzzling threefold replication of the elementary particles known as quarks and leptons; these particles provide the foundations for the structure of atoms. This theory project seeks to do so in the context of a concentrated worldwide experimental program whose objective is to produce hugely more information about the mysterious replication. Expected outcomes include the con ....New Physics and the quark/lepton family replication puzzle. This project aims to investigate how new physics impacts on the puzzling threefold replication of the elementary particles known as quarks and leptons; these particles provide the foundations for the structure of atoms. This theory project seeks to do so in the context of a concentrated worldwide experimental program whose objective is to produce hugely more information about the mysterious replication. Expected outcomes include the construction of new theories that deepen our understanding of elementary particles and their interactions. This should provide significant benefits to intellectual culture and the training of early-career researchers as flexible problem solvers able to innovate in any context in industry or government service.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100076
Funder
Australian Research Council
Funding Amount
$150,068.00
Summary
Australian Participation in the Belle II Experiment. Australian participation in the Belle II experiment: This project will provide membership for Australian scientists of one of the key contemporary particle physics experiments, the Belle II experiment in Japan, and contribute to the purchase and installation of equipment for the Japanese facility. The Belle II experiment aims to search for a deeper theory of nature which will add significantly to our ability to answer questions such as why the ....Australian Participation in the Belle II Experiment. Australian participation in the Belle II experiment: This project will provide membership for Australian scientists of one of the key contemporary particle physics experiments, the Belle II experiment in Japan, and contribute to the purchase and installation of equipment for the Japanese facility. The Belle II experiment aims to search for a deeper theory of nature which will add significantly to our ability to answer questions such as why there is a preponderance of matter over antimatter in the Universe, and what is the nature of the dark matter which pervades it. This project will allow Australian scientists to pursue these questions in the coming years, with the additional benefit of increasing Australia's research profile in fundamental physics and its engagement with basic science in the Asia-Pacific region.Read moreRead less
In search of the origin of mass at the Large Hadron Collider. This project will utilise new theoretical ideas and worldwide experimental efforts at the Large Hadron Collider with the aim to resolve one of the most profound mysteries of modern physics, the origin of mass in the universe. The results will have an important longstanding impact by promoting innovation culture and public education of science.
Targeting Bone Marrow Mediated Angiogenesis And Metastasis In Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$463,006.00
Summary
Despite advances in treatment and diagnostics breast cancer (BC) remains one of the leading causes of death in women. Metastases and tumour blood vessel recruitment are linked. Work by Dr Mellick and others has shown that host bone marrow contributes endothelial progenitor cells (EPCs) to tumour vasculature. The chemokines and their receptors, which differentiate EPCs from tumour vessels, will be knocked down in the tumour cells and EPC progenitors with the aim of preventing tumour spread.
ARC Centre of Excellence in Plants for Space. ARC Centre of Excellence in Plants for Space. This Centre aims to create on-demand, zero-waste, high-efficiency plants and plant products to address grand challenges in sustainability for Space and on Earth. Significant advances in plant, food, and sensory science; process and systems engineering; law and policy; and psychology are expected to deliver transformative solutions for Space habitation – and create enhanced plant-derived food and bioresour ....ARC Centre of Excellence in Plants for Space. ARC Centre of Excellence in Plants for Space. This Centre aims to create on-demand, zero-waste, high-efficiency plants and plant products to address grand challenges in sustainability for Space and on Earth. Significant advances in plant, food, and sensory science; process and systems engineering; law and policy; and psychology are expected to deliver transformative solutions for Space habitation – and create enhanced plant-derived food and bioresources to capitalise upon emergent and rapidly expanding domestic and global markets. Anticipated outcomes include industry uptake of innovative plant forms, foods, technologies, and commodities; and an ambitious education and international co-ordination agenda to position Australia as a global leader in research supporting Space habitation.Read moreRead less