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Evolution And Pathogenicity Of NDM-1 Positive Escherichia Coli
Funder
National Health and Medical Research Council
Funding Amount
$643,275.00
Summary
Antibiotic resistance (AR), as highlighted by the WHO, is the most pressing medical need of the 21C – some infections are now untreatable. Our research will focus on the new "superbug" NDM-1 positive E. coli. We will correlate AR and pathogenicity and explore the evolution of these "superbugs" using state-of-the-art sequencing. This research will benefit Australian medicine by predicting timelines of AR epidemics and by conducting the first analyses on the virulence potential of these strains.
Strain-level Characterisation And Visualisation Of The Mucosal Microbial Communities Associated With Inflammatory Bowel Disease (IBD) For The Development Of Novel Biotherapeutics
Funder
National Health and Medical Research Council
Funding Amount
$1,181,878.00
Summary
Australia has one of the highest incidence rates in the world of Inflammatory Bowel Disease (IBD), a debilitating inflammatory condition of the gastrointestinal tract. Cutting-edge molecular and visualisation technologies will be used to examine the role of the gut microbiome in IBD, and identify specific members of this community to be used as new therapies to suppress inflammation and improve outcomes for patients with IBD.
Molecular Cell Biology and Comparative Genomics Of Planctomycetes and Verrucomicrobia In Relation To Evolution Of Cytoskeletal Proteins and Membrane-bounded Compartments. Planctomycetes and verrucomicrobia are evolutionarily distinct groups of bacteria which possess unusual cell structure and which share some significant genes important in cell biology with eukaryotes e.g. in verrucomicrobia the cytoskeleton protein tubulin. These bacteria are important for understanding the transition from no ....Molecular Cell Biology and Comparative Genomics Of Planctomycetes and Verrucomicrobia In Relation To Evolution Of Cytoskeletal Proteins and Membrane-bounded Compartments. Planctomycetes and verrucomicrobia are evolutionarily distinct groups of bacteria which possess unusual cell structure and which share some significant genes important in cell biology with eukaryotes e.g. in verrucomicrobia the cytoskeleton protein tubulin. These bacteria are important for understanding the transition from non-nucleated cells with simple cell division to nucleated cells with chromosome separation via cytoskeletal protein movement.The project will compare genomes of of planctomycetes and verrucomicrobia to determine their relationship, determine whether the tubulin homolog of verrucomicrobia can form cytoskeleton structures, and characterize the cytoskeleton of ammonium-oxidizing planctomycetes used in wastewater treatment.Read moreRead less
Development of symbiont based approaches to pest and disease control in sugarcane. This project aims to develop a new approach to the control of insect damage to sugarcane in Australia. It focuses on the manipulation of bacteria that are intimately associated with insects that feed on sugarcane, so as to decrease their ability to cause crop damage both directly through feeding and indirectly through the transmission of disease
Rapid functional and taxonomic skin microbe characterisation. Rapid functional and taxonomic skin microbe characterisation. This project aims to develop methods to detect and characterise bioactive molecules released by skin microbes, and a novel microspectroscopy method for rapid taxonomic identification. This project will acquire independent spectra and develop classification algorithms, and participate in strategic planning for applications and product development. The expected outcomes from ....Rapid functional and taxonomic skin microbe characterisation. Rapid functional and taxonomic skin microbe characterisation. This project aims to develop methods to detect and characterise bioactive molecules released by skin microbes, and a novel microspectroscopy method for rapid taxonomic identification. This project will acquire independent spectra and develop classification algorithms, and participate in strategic planning for applications and product development. The expected outcomes from this project are research tools for skin microbiome modulation of immunity, and proof-of-concept data for future commercial product development. Potential commercial applications include microbial characterisation for biosecurity, agriculture, environmental and soil biology.Read moreRead less
Defining domains within Mycoplasma hyopneumoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine. Over 90% of Australian commercial pig production facilities are affected by Mycoplasma hyopneumoniae, the causative agent of swine enzootic pneumonia. This disease causes economic losses in Australia of over $20 million per annum and up to $1 billion per annum in major swine rearing countries worldwide. This project will determine the p ....Defining domains within Mycoplasma hyopneumoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine. Over 90% of Australian commercial pig production facilities are affected by Mycoplasma hyopneumoniae, the causative agent of swine enzootic pneumonia. This disease causes economic losses in Australia of over $20 million per annum and up to $1 billion per annum in major swine rearing countries worldwide. This project will determine the protective efficacy of new generation vaccines against M. hyopneumoniae, which aim to block the colonisation process and prevent disease .Read moreRead less
Autotransporter proteins of enterohemorrhagic Escherichia coli O157:H7. Escherichi (E.) coli O157:H7 has caused hundreds of outbreaks in the United States and United Kingdom. Although not currently a major problem in Australia, the emergence of E. coli O157:H7 here would have serious implications for our meat and livestock industry. This study will provide important information for the selection of vaccine antigens used to prevent the colonisation of cattle with E. coli O157:H7 and other diarrho ....Autotransporter proteins of enterohemorrhagic Escherichia coli O157:H7. Escherichi (E.) coli O157:H7 has caused hundreds of outbreaks in the United States and United Kingdom. Although not currently a major problem in Australia, the emergence of E. coli O157:H7 here would have serious implications for our meat and livestock industry. This study will provide important information for the selection of vaccine antigens used to prevent the colonisation of cattle with E. coli O157:H7 and other diarrhoeagenic E. coli serotypes. A direct outcome of this will be improved human health, as E. coli O157:H7 can cause life threatening infections in humans. The study will also examine the contribution of specific adhesins to biofilm formation; measures to prevent biofilm formation may reduce the persistence and spread of E. coli O157:H7 in the environment.Read moreRead less
Special Research Initiatives - Grant ID: SR0354702
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian Microbial Resources Research Network. The Australian Microbial Resources Research Network will provide integrated access to Australian collections of microorganisms and electronic access to bioinformation databases to meet national strategic needs for microbiological resources and to support the competitive development of the life sciences and biotechnology industries in Australia. The network will promote collaborative interactions and accelerate the discovery of Australian microorg ....Australian Microbial Resources Research Network. The Australian Microbial Resources Research Network will provide integrated access to Australian collections of microorganisms and electronic access to bioinformation databases to meet national strategic needs for microbiological resources and to support the competitive development of the life sciences and biotechnology industries in Australia. The network will promote collaborative interactions and accelerate the discovery of Australian microorganisms and microbial genomic information for innovative biotechnology and create new opportunities for bioindustries. The Network will link researchers and foster the discovery and exploitation of Australian microbial resources and make these resources and associated information available for applications in research, industry and education.Read moreRead less
Mapping cell wall and surface structures of Gram-positive cocci. The synthesis of the Gram-positive cell wall and protein transport are fundamental processes, the improved understanding of which will impact across a range of fields including microbiology, biochemistry and biotechnology, and the application and manipulation of Gram-positive bacteria in agriculture, industry and human health. In the long-term, the analysis of the Gram-positive ExPortal and cell wall will identify proteins that ma ....Mapping cell wall and surface structures of Gram-positive cocci. The synthesis of the Gram-positive cell wall and protein transport are fundamental processes, the improved understanding of which will impact across a range of fields including microbiology, biochemistry and biotechnology, and the application and manipulation of Gram-positive bacteria in agriculture, industry and human health. In the long-term, the analysis of the Gram-positive ExPortal and cell wall will identify proteins that may represent targets for therapeutic intervention. Additionally a precise understanding of the mechanisms of secretion of anchorless proteins will have an important impact in the biotechnology field, as new methodologies for the secretion of recombinant proteins of industrial value is a potential outcome.Read moreRead less
Exploring the role of the domestic dog and wild rodents as peri-domestic reservoirs of Rickettsia felis. This project aims to explore the role of domestic dogs and wild rats as maintenance hosts for flea-borne spotted fever. Cases of this disease, transmitted to humans by the common dog and cat flea are being increasingly recognised throughout the world. The findings of this study will add significant importance to flea control in pets.