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A Novel One-step Approach In The Early Diagnosis Of Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$102,150.00
Summary
In order to avoid the invasiveness and imprecision of current prostate cancer detection, this programme is directed to developing a non-invasive and repeatable, accurate approach. This research project is designed to optimise retrieval of prostate cells from ejaculate and to compare two methods for profiling selected genetic changes to diagnose prostate cancer. The refinement of techniques, outlined in the application, is essential before proceeding to a clinical trial.
The majority of deaths from cancer are due to metastasis, which is the formation of secondary tumours at sites remote from the primary tumour. Metastasis involves conversion of some tumour cells to an invasive, migratory form in a process that is controlled by small genetic regulators known as microRNAs. In this project we will conduct experiments aimed to provide a proof of principle demonstration in mice that microRNAs can be used to block the formation of metastases.
Novel Nanoparticle Composites For Molecular Probes In Diagnostic Imaging
Funder
National Health and Medical Research Council
Funding Amount
$170,716.00
Summary
Isotope labelled protein probes, eg. antibodies, are a valuable imaging tool in investigating patient disease. Their biological specificity is their great strength, however, detection sensitivity often limits their use. A novel nanoparticle developed at ANU can increase this signal by a million-fold in comparison with conventional methods of labelling. This approach suits a range of probes and will accommodate many of the isotopes already used in patient diagnostics and therapy.