Vascular Cognitive Risk Score: Quantifying The Vascular Burden In Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$627,180.00
Summary
What causes dementia in a patient presenting to a clinic is often uncertain. While there are exciting potential treatments in the pipeline, we need to understand the cause of the disease in a specific patient to make correct treatment decisions. Stroke and other vascular diseases of the brain cause a significant proportion of dementia in the community. Using MRI scanning technology, this project will quantify this burden in a given patient by developing a ‘vascular cognitive risk' (VCR) score.
What Can Tau Deposition Tell Us About The Appearance Of Subjective And Objective Cognitive Decline In Older Adults?
Funder
National Health and Medical Research Council
Funding Amount
$674,077.00
Summary
Subjective memory concerns are common in older adults, but it is uncertain how they relate to Alzheimer’s disease (AD) biomarkers. Novel neuroimaging techniques have been developed for measuring tau deposition, a hallmark feature of AD. Using this technique, I aim to determine whether tau is sensitive to certain types of subjective concerns. My findings will reveal which concerns are indicative of AD risk, and which arise from unrelated factors, such as inattention or stress.