Haemodynamic investigation of flow diverter stents for the treatment of intracranial aneurysms. This project will explore the engineering of a flow diverter, an endovascular device for the treatment of brain aneurysms. The project will determine the optimal design of new types of flow diverters, which in turn could improve the effectiveness of treatments, thus reducing the associated costs of cerebral haemorrhage and stroke.
New Imaging Agents for Neuronal Nicotinic Receptors. Recent advances in medical imaging technology such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) have radically improved the diagnosis and treatment of a wide range of diseases. The aim of this project is to discover novel radio-ligands that selectively bind to neuronal nicotinic acetylcholine receptors. These ligands will have great potential for the imaging, diagnosis and study of neurodegenerat ....New Imaging Agents for Neuronal Nicotinic Receptors. Recent advances in medical imaging technology such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) have radically improved the diagnosis and treatment of a wide range of diseases. The aim of this project is to discover novel radio-ligands that selectively bind to neuronal nicotinic acetylcholine receptors. These ligands will have great potential for the imaging, diagnosis and study of neurodegenerative diseases such as Alzheimer's disease. Read moreRead less
Flavour enhancing functional feeds for farmed Barramundi. This project aims to improve the flavour quality of Australian farmed barramundi through developing novel functional feeds. The project expects to expand our fundamental knowledge of flavour enhancement, whilst providing practical benefits with respect to final product quality. The project will enable industry to achieve higher product quality benchmarks, towards the ultimate goal of improving the marketability of barramundi both locally ....Flavour enhancing functional feeds for farmed Barramundi. This project aims to improve the flavour quality of Australian farmed barramundi through developing novel functional feeds. The project expects to expand our fundamental knowledge of flavour enhancement, whilst providing practical benefits with respect to final product quality. The project will enable industry to achieve higher product quality benchmarks, towards the ultimate goal of improving the marketability of barramundi both locally and overseas. This project will provide significant benefits to the Australian barramundi industry by increasing product values, thereby facilitating an economically sustainable growth of this important regional industry.Read moreRead less
Unlocking the potential of quantitative x-ray micro-tomography. This project aims to build on two new ideas in data acquisition and 3D image reconstruction to bring 3D X-ray microscopy or computed tomography (CT) into advanced research use as well as common industrial applications. In the past 10 years, CT has improved our understanding in areas ranging from the evolution of life and osteoporosis to composite material failure and oil recovery. However, the full potential of CT remains unrealised ....Unlocking the potential of quantitative x-ray micro-tomography. This project aims to build on two new ideas in data acquisition and 3D image reconstruction to bring 3D X-ray microscopy or computed tomography (CT) into advanced research use as well as common industrial applications. In the past 10 years, CT has improved our understanding in areas ranging from the evolution of life and osteoporosis to composite material failure and oil recovery. However, the full potential of CT remains unrealised because crucial features in structure and composition are overlooked by simplistic algorithms. Users cannot directly capture quantities of interest such as key compositional variation or defects, and workflows are poorly adapted for large-scale use in industrial fabrication or phenomics. This project aims to address these shortcomings using advanced mathematics and algorithms.Read moreRead less
Insoluble-fibre enriched beverages. Insoluble-fibre enriched beverages. This project aims to develop healthy new beverages, by studying the effect of chemistry and physical interactions of insoluble dietary fibre with other food ingredients. Insoluble fibre reduces the risk of chronic diseases, including cardiovascular disease, cancer and diabetes. This project will research how insoluble-fibre linked phytochemicals behave in complex matrices and contribute to malodorous flavours; and design adv ....Insoluble-fibre enriched beverages. Insoluble-fibre enriched beverages. This project aims to develop healthy new beverages, by studying the effect of chemistry and physical interactions of insoluble dietary fibre with other food ingredients. Insoluble fibre reduces the risk of chronic diseases, including cardiovascular disease, cancer and diabetes. This project will research how insoluble-fibre linked phytochemicals behave in complex matrices and contribute to malodorous flavours; and design advanced experimental protocols to prevent undesirable sensory characteristics in liquid systems.Read moreRead less
Novel methods for the production of micronutrient-enriched rice. The increasingly productive Australian rice industry generated AUD$1 billion revenue in 2012. By targeting a rice gene that we recently identified as a key regulator of iron uptake and transport, this project will produce high value, micronutrient-enriched rice grain to improve the nutritional health of people in Australia and throughout the world.
Advanced plant breeding and food manufacturing for healthier bread. This project aims to generate bread containing high amounts of biologically available iron through targeted manipulation of plant-derived phytonutrients at several points along the wheat-to-bread supply chain. The project expects to generate new knowledge for developing healthier bread and address consumer demands for value-added food products. Anticipated outcomes are novel plant breeding and food manufacturing techniques that ....Advanced plant breeding and food manufacturing for healthier bread. This project aims to generate bread containing high amounts of biologically available iron through targeted manipulation of plant-derived phytonutrients at several points along the wheat-to-bread supply chain. The project expects to generate new knowledge for developing healthier bread and address consumer demands for value-added food products. Anticipated outcomes are novel plant breeding and food manufacturing techniques that enhance the nutritional composition of wheat grain and bread making products, resulting in higher-value agricultural commodities and breads. The project should benefit bread retailers and crop growers involved in Australia’s $4.7 billion bread market and reduce the environmental impacts of bread production.Read moreRead less
Australia’s first direct-detection dark matter search, at Stawell Gold Mine. This project aims to develop an underground integrated laboratory at Stawell Gold Mine in Victoria to host the Southern Hemisphere's first-ever direct-detection dark matter experiment. Following the Higgs boson discovery, the direct detection of dark matter is seen as the next major challenge for particle physics. This project sees Australian physicists team up with local and international partners in research and indus ....Australia’s first direct-detection dark matter search, at Stawell Gold Mine. This project aims to develop an underground integrated laboratory at Stawell Gold Mine in Victoria to host the Southern Hemisphere's first-ever direct-detection dark matter experiment. Following the Higgs boson discovery, the direct detection of dark matter is seen as the next major challenge for particle physics. This project sees Australian physicists team up with local and international partners in research and industry to join the search for dark matter. This Australian experiment aims to help to confirm or deny current results from Northern Hemisphere experiments. As the mine nears the end of its working life as a gold mine, this project is expected to benefit the local economy and provide opportunities for education and outreach.Read moreRead less
Saving Nemo: Reducing animal use in toxicity assessments of wastewater. Every day, Australians produce ~5 billion litres of wastewater, which contains a cocktail of chemicals. Industries that discharge wastewater are required to assess chemical risks to the receiving environments by conducting whole animal direct toxicity assessments (DTA), which are expensive and pose an ethical dilemma. Our preliminary research shows that new in vitro bioassays provide an ethical and cost effective alternative ....Saving Nemo: Reducing animal use in toxicity assessments of wastewater. Every day, Australians produce ~5 billion litres of wastewater, which contains a cocktail of chemicals. Industries that discharge wastewater are required to assess chemical risks to the receiving environments by conducting whole animal direct toxicity assessments (DTA), which are expensive and pose an ethical dilemma. Our preliminary research shows that new in vitro bioassays provide an ethical and cost effective alternative that could be incorporated into DTA programs if their ecological relevance can be demonstrated. This project will develop and validate a new and internationally significant suite of in vitro bioassays for incorporation into DTA programs, leading to more ethical, cost effective and improved environmental protection.Read moreRead less
New insulins for the improved management of diabetes. The prevalence of diabetes has increased dramatically over the past few decades and now this condition is widely considered the world’s fastest growing disease. New insulins with improved pharmacological and storage properties are desperately needed, and this project will work on chemical synthesis enabling designer insulins to be prepared for improved management of diabetes.