Heavy atoms and ions and precision tests of fundamental physics. This project aims to further the understanding of the structure of heavy atoms through development and application of state-of-the-art many-electron methods. Atomic physics is undergoing a period of rapid growth with a new generation of experiments underway across different areas in fundamental physics. This includes testing particle physics at low energies, opening a new realm of discovery with the synthesis and interrogation of s ....Heavy atoms and ions and precision tests of fundamental physics. This project aims to further the understanding of the structure of heavy atoms through development and application of state-of-the-art many-electron methods. Atomic physics is undergoing a period of rapid growth with a new generation of experiments underway across different areas in fundamental physics. This includes testing particle physics at low energies, opening a new realm of discovery with the synthesis and interrogation of superheavy elements, and the development of atomic clocks of ever-increasing precision. The expected benefit will be to increase capability in fundamental physics tests and in the development of precision atomic instruments.Read moreRead less
Trapped Ion Imaging for Biomolecular Dynamics. The functionality of large biological molecules is driven by their chemical composition and the folded shape of their active form. The higher-order structure and dynamics of nucleic acids, proteins, carbohydrates, and lipids drives the chemistry of life. Combining single molecule microscopy and trapped ion mass spectroscopy will develop a new tool for precision measurements of higher-order folding dynamics in large biomolecules. Optical techniques i ....Trapped Ion Imaging for Biomolecular Dynamics. The functionality of large biological molecules is driven by their chemical composition and the folded shape of their active form. The higher-order structure and dynamics of nucleic acids, proteins, carbohydrates, and lipids drives the chemistry of life. Combining single molecule microscopy and trapped ion mass spectroscopy will develop a new tool for precision measurements of higher-order folding dynamics in large biomolecules. Optical techniques including Förster resonance energy transfer and super-resolution imaging can register changes in shape down to the nanometer scale. The uniquely adaptable ion trap environment enables manipulation of the surrounding solvent cage, temperature, and net charge down to the single quantum level. Read moreRead less
Adaptive evolution of coleoid (cuttlefish, octopus, squid) venoms. This project represents an opportunity for biodiscovery from the venoms of cuttlefish, octopuses and squids. The independent adaptation for venom active at the subzero Arctic and Antarctic polar waters is of particular evolutionary interest. However, their divergent, bioactive compounds are also a rich drug design resource.
Converging on new particles and fundamental symmetries. The goal of this project is to test theories for new particles and fundamental symmetries. By using advanced computational and statistical methods to combine all relevant data from many different experiments with a large number of different theoretical predictions, it expects to reveal just how well different theories actually describe reality. This will help us to understand what new particles and fundamental symmetries exist beyond thos ....Converging on new particles and fundamental symmetries. The goal of this project is to test theories for new particles and fundamental symmetries. By using advanced computational and statistical methods to combine all relevant data from many different experiments with a large number of different theoretical predictions, it expects to reveal just how well different theories actually describe reality. This will help us to understand what new particles and fundamental symmetries exist beyond those we already know. It will lead to new algorithms and computational methods in machine learning and statistical sampling, and will train a cohort of graduates highly skilled in statistical data science and research computing.Read moreRead less
Bioactive Peptides as Pharmacological Tools and Novel Drug Leads. Bioactive peptides are produced by all organisms and play numerous critical physiological roles, including in cellular communication, host defence and capture of prey. Peptides have huge potential as tools for studying roles of signalling pathways and as novel drugs due to their high affinity and selectivity for various therapeutically relevant targets. However their use has been limited by poor in vivo stability. This project is ....Bioactive Peptides as Pharmacological Tools and Novel Drug Leads. Bioactive peptides are produced by all organisms and play numerous critical physiological roles, including in cellular communication, host defence and capture of prey. Peptides have huge potential as tools for studying roles of signalling pathways and as novel drugs due to their high affinity and selectivity for various therapeutically relevant targets. However their use has been limited by poor in vivo stability. This project is focused on studying structural features of a range of peptides and their contributions to both activity and to resistance against degradation, with the aim to develop stabilised bioactive peptide sequences for in vivo applications, allowing the full potential of peptides as drugs to be realised.Read moreRead less
Novel devices for spatial light transformation. The aim of this project is to develop new optical instrumentation for spatially transforming light. This research expects to find solutions to problems that have thus far been out of reach by replacing what would traditionally be a human optical systems designer with computer algorithms. The expected outcomes include the development of three new devices as well as a set of design, fabrication and characterisation procedures that offer higher perfor ....Novel devices for spatial light transformation. The aim of this project is to develop new optical instrumentation for spatially transforming light. This research expects to find solutions to problems that have thus far been out of reach by replacing what would traditionally be a human optical systems designer with computer algorithms. The expected outcomes include the development of three new devices as well as a set of design, fabrication and characterisation procedures that offer higher performance, increased robustness and scalability. This should improve accessibility of this technology and provide benefits to a wide range of applications, including astronomical and biomedical imaging, telecommunications, as well as quantum and classical optical signal processing.Read moreRead less
Two-dimensional quantum turbulence in superfluid atomic gases. This project will controllably generate and study turbulence in two-dimensional superfluids. With quantum fluids as models to understand two-dimensional fluid dynamics, this project aims to provide a better generic understanding of physical mechanisms behind phenomena as diverse as cyclone dynamics and the stability of the planet Jupiter's Great Red Spot.
Development of effective peptide-based drugs. There is huge interest in the development of bioactive peptides and proteins for the treatment of a wide range of diseases. The aim of this research project is to develop potent and effective peptide-based drugs that are able to resist the body's natural degradation pathways so that they can reach their biological target and act as effective drugs.
A new Src, PKCdelta and Akt regulated protease activated receptor system in metastasis. In contrast with localised cancer which can often be cured, curative treatment is generally not possible for cancer that has spread. This project will characterise a protein that drives the spread of cancer and to develop new approaches to treat patients at risk of developing these aggressive tumours that spread to other organs.
Organic-inorganic hybrid electronic devices and logic circuits. This project will create the next generation of opto-electronic devices and logic circuits using solution-based organic-inorganic hybrid materials with the potential to be extremely cheap, recyclable, and mechanically flexible. This project aims to position Australia as a leader in printed electronics.