Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882531
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Quantum Limited Single Atom Detectors. The technology that has shaped our society, solid state diodes, transistors and computer chips is based on our ability to manipulate the average quantum properties of materials such as semiconductors. This physics has been well understood for decades. Many technologies that will shape our societies in this century will be based on our ability to manipulate quantum systems precisely, an area that is the focus of quantum atom optics. The detectors requested i ....Quantum Limited Single Atom Detectors. The technology that has shaped our society, solid state diodes, transistors and computer chips is based on our ability to manipulate the average quantum properties of materials such as semiconductors. This physics has been well understood for decades. Many technologies that will shape our societies in this century will be based on our ability to manipulate quantum systems precisely, an area that is the focus of quantum atom optics. The detectors requested in this proposal will ensure that Australia remains competitive in the technologies that will emerge from the new field of quantum atom optics.Read moreRead less
Time-space resolved photoelectron emission to control molecular processes. This project aims to resolve simultaneously the timing and space localisation of photoelectron emission from atoms and molecules as a means for targeted breaking of molecular bonds. Existing techniques determine the timing and spatial characteristics of photoemission independently. The simultaneous time-space resolution will allow for the precise manipulation of photoelectrons by a sequence of phase-stabilised laser pulse ....Time-space resolved photoelectron emission to control molecular processes. This project aims to resolve simultaneously the timing and space localisation of photoelectron emission from atoms and molecules as a means for targeted breaking of molecular bonds. Existing techniques determine the timing and spatial characteristics of photoemission independently. The simultaneous time-space resolution will allow for the precise manipulation of photoelectrons by a sequence of phase-stabilised laser pulses, a technique known as coherent control. The benefit of this project will be the coherently controlled breaking of molecular bonds in oxide, carbonyl and hydrocarbon molecules. The outcome will be a significant step forward in driving complex photochemical reactions in industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453256
Funder
Australian Research Council
Funding Amount
$512,573.00
Summary
National Positron Beamline Facility. We shall construct an experimental facility for the study of positron interactions with atoms, molecules and condensed matter. It will
- Provide a unique Australian facility for the study of positron interactions with matter
- Provide benchmark data for low energy positron interactions with atoms and molecules and a reference point for theoretical calculations
- Provide Australian materials scientists with a new tool for the development of novel material ....National Positron Beamline Facility. We shall construct an experimental facility for the study of positron interactions with atoms, molecules and condensed matter. It will
- Provide a unique Australian facility for the study of positron interactions with matter
- Provide benchmark data for low energy positron interactions with atoms and molecules and a reference point for theoretical calculations
- Provide Australian materials scientists with a new tool for the development of novel materials and thin film technology
- Provide new insight on the mechanisms of positron binding to matter
- Address a National Research Priority: Frontier Technologies for Building and Transforming Australian Industries.
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Australian Centre for Quantum-Atom Optics. The Centre will combine pre-eminent Australian theoretical and experimental research groups in quantum and atom optics to create a powerful network to advance the rapidly developing field of Quantum-Atom Optics. We will exploit the quantum nature of multiple particle quantum states of atoms and photons including entangled light and Bose-Einstein condensates. The Centre will focus on fundamental research, but our long term goal is to underpin and develo ....Australian Centre for Quantum-Atom Optics. The Centre will combine pre-eminent Australian theoretical and experimental research groups in quantum and atom optics to create a powerful network to advance the rapidly developing field of Quantum-Atom Optics. We will exploit the quantum nature of multiple particle quantum states of atoms and photons including entangled light and Bose-Einstein condensates. The Centre will focus on fundamental research, but our long term goal is to underpin and develop the next generation quantum technology. We aim to build a quantum toolbox to enable applications such as the transfer and storage of information for photonics, and precision quantum control of atoms for enhanced atom interferometry.Read moreRead less
Unsaturation of vapour pressure inside leaves: fundamental, but unknown. This project aims to determine when and to what extent the air inside leaves becomes unsaturated with water vapour. All current interpretation and modelling of leaf gas exchange assumes saturation under all circumstances. Compelling evidence has been obtained that suggests this is not true under moderate air vapour pressure deficits. A novel technique will be employed to assess the water vapour concentration of the air insi ....Unsaturation of vapour pressure inside leaves: fundamental, but unknown. This project aims to determine when and to what extent the air inside leaves becomes unsaturated with water vapour. All current interpretation and modelling of leaf gas exchange assumes saturation under all circumstances. Compelling evidence has been obtained that suggests this is not true under moderate air vapour pressure deficits. A novel technique will be employed to assess the water vapour concentration of the air inside leaves based on stable isotope analysis of carbon dioxide and water vapour exchanged between leaves and air. The project is expected to provide fundamental knowledge about how stomata regulate photosynthesis and water use, with significant implications for modelling vegetation function and for improving the performance of crop plants.Read moreRead less
ARC Centre of Excellence - Centre for Antimatter-Matter Studies. While our world is made of matter, all particles have anti-particles and the most abundant is the positron, the electron's antiparticle. It is the "workshop" for most anti-matter studies, particularly for the characterization of materials, including gases, polymers, insulators, thin films and surfaces, as well as the development of new and novel, nano-structured materials. The ARC Centre of Excellence in Antimatter-Matter Studies ....ARC Centre of Excellence - Centre for Antimatter-Matter Studies. While our world is made of matter, all particles have anti-particles and the most abundant is the positron, the electron's antiparticle. It is the "workshop" for most anti-matter studies, particularly for the characterization of materials, including gases, polymers, insulators, thin films and surfaces, as well as the development of new and novel, nano-structured materials. The ARC Centre of Excellence in Antimatter-Matter Studies (CAMS) will bring together key Australian and international scientists to work in this emerging scientific field of antimatter-matter interactions. It will forge a unique and effective scientific team for state-of-the-art studies of the nano-world that underlies many everyday processes and new technologies.Read moreRead less
Positrons in biosystems. This project aims to improve our understanding of the damage processes in Positron Emission Tomography (PET). PET is a widely used medical imaging technique, but there are gaps in our understanding of the underlying interactions, in particular in the case of the radiation damage induced during the process. By using new models incorporating accurate descriptions of interactions processes, verified by experimental measurement, this project will develop a new model of posit ....Positrons in biosystems. This project aims to improve our understanding of the damage processes in Positron Emission Tomography (PET). PET is a widely used medical imaging technique, but there are gaps in our understanding of the underlying interactions, in particular in the case of the radiation damage induced during the process. By using new models incorporating accurate descriptions of interactions processes, verified by experimental measurement, this project will develop a new model of positron transport in PET. The project will allow validation of predictions from the model by undertaking experiments in liquid water.Read moreRead less
Atomic scale imaging with high coherence electrons and ions. This project aims to combine a cold atom electron-ion source with a commercial microscope column for atomic-scale imaging in biosciences and materials science. Nanoscale imaging with electron and ion microscopy are tools for investigating the world at the atomic scale, underpinning development in modern technologies from semiconductor devices to medical treatments. This project will use ideas from laser cooling of atoms and atom optics ....Atomic scale imaging with high coherence electrons and ions. This project aims to combine a cold atom electron-ion source with a commercial microscope column for atomic-scale imaging in biosciences and materials science. Nanoscale imaging with electron and ion microscopy are tools for investigating the world at the atomic scale, underpinning development in modern technologies from semiconductor devices to medical treatments. This project will use ideas from laser cooling of atoms and atom optics to achieve new imaging modalities for time-lapse imaging of fundamental processes at the nano-scale. It will allow increasingly small scale resolution of fundamental processes at the nano-scale.Read moreRead less
Will stomatal responses to humidity and carbon dioxide constrain tropical forest productivity as atmospheric carbon dioxide rises? This project will investigate two physiological processes that will partly determine growth responses of tropical forest trees to rising atmospheric carbon dioxide. The project will produce equations summarising physiological responses that can be incorporated into process-based models of tropical forest productivity.