From risk factor analysis to translation: multiple sclerosis and vitamin D deficiency. This research on multiple sclerosis will focus on its causes and lifestyle factors that affect it and will trial vitamin D supplementation as a treatment. Studies on vitamin D deficiency in healthy populations aim to develop new public health recommendations on sun exposure and vitamin D that balance risk of skin cancer against vitamin D deficiency.
Elucidating the molecular mechanisms underlying migraine and endometriosis via genetic dissection. The research aims to identify genetic variants underlying migraine and endometriosis susceptibility. Advances in the genetics of these common and painful disorders, including identification of genetic biomarkers (genetic variations that can predict disease susceptibility, disease outcome, or treatment response), will offer better rationales for scientific enquiry, helping the discovery of new treat ....Elucidating the molecular mechanisms underlying migraine and endometriosis via genetic dissection. The research aims to identify genetic variants underlying migraine and endometriosis susceptibility. Advances in the genetics of these common and painful disorders, including identification of genetic biomarkers (genetic variations that can predict disease susceptibility, disease outcome, or treatment response), will offer better rationales for scientific enquiry, helping the discovery of new treatment pathways and improve predictions of drug efficacy and safety. Thus providing improved treatment strategies for the individual sufferer and reduce the direct medical and indirect economic costs to individual sufferers as well as to the general community.Read moreRead less
Spin-orbit-coupled Bose-Einstein Condensates. This project will explore fundamentally new quantum states, the spin-orbit Bose-Einstein condensates, predicted theoretically by Galitski et al. and subsequently observed experimentally. These states host a variety of fascinating novel phenomena, which can be exploited for ultra-sensitive interferometry and topological quantum computing. The project will develop a complete description of these phases and design new quantum devices that utilise their ....Spin-orbit-coupled Bose-Einstein Condensates. This project will explore fundamentally new quantum states, the spin-orbit Bose-Einstein condensates, predicted theoretically by Galitski et al. and subsequently observed experimentally. These states host a variety of fascinating novel phenomena, which can be exploited for ultra-sensitive interferometry and topological quantum computing. The project will develop a complete description of these phases and design new quantum devices that utilise their properties. The fundamental significance of the project is in bringing together ideas from the diverse fields of atomic and molecular physics, condensed matter, quantum information, and topology and its direct relevance to the development of a new generation of quantum devices.Read moreRead less
Collision physics in lighting, fusion and astrophysical plasmas. The project will apply advanced fundamental science techniques to applications that have a high impact on the environment. These include improving energy efficiency of fluorescent lamps and development of new mercury-free designs and research in support of the international multi-billion dollar fusion energy program.
Understanding somatic mutation in plants: new methods, new software, new data. Somatic mutations accumulate as plants grow, affecting everything from short-term ecological interactions to long-term evolutionary dynamics. These mutations have important consequences for plant industry and conservation, but because they are so hard to measure almost nothing is known about them. This project aims to develop new methods and software to detect, analyse, and compare the genome-wide history of somatic m ....Understanding somatic mutation in plants: new methods, new software, new data. Somatic mutations accumulate as plants grow, affecting everything from short-term ecological interactions to long-term evolutionary dynamics. These mutations have important consequences for plant industry and conservation, but because they are so hard to measure almost nothing is known about them. This project aims to develop new methods and software to detect, analyse, and compare the genome-wide history of somatic mutation in individual plants, providing an unprecedented level of detail into an important but understudied source of biological variation. By applying these methods to an iconic experimental population, This project aims to provide the first insights into the genome-wide causes and consequences of somatic mutation in plants.Read moreRead less
Dietary patterns across the life-course: implications for the prevention of obesity, cardiometabolic disease and public health. This research will focus on dietary patterns in population health across the life-course. We know little about how dietary patterns and their determinants vary across life and the impact of life-stage transitions on diet and health. This research will provide insights into dietary patterns of infants, children, young adults and older adults.
Using mathematical modelling to inform HIV/AIDS public health policy. This research will directly inform HIV/AIDS policy officials on the most effective strategies for preventing new cases in HIV in the community. Consequently, there are health benefits for Australia and for the other countries in which the research is being conducted. HIV/AIDS community groups, educators, and other advocacy groups will also be engaged in the research, leading to the development of focussed prevention campaigns ....Using mathematical modelling to inform HIV/AIDS public health policy. This research will directly inform HIV/AIDS policy officials on the most effective strategies for preventing new cases in HIV in the community. Consequently, there are health benefits for Australia and for the other countries in which the research is being conducted. HIV/AIDS community groups, educators, and other advocacy groups will also be engaged in the research, leading to the development of focussed prevention campaigns by these stakeholders to inform the appropriate communities. Reducing the health burdens of HIV/AIDS will also have economic benefits.Read moreRead less
Generating evidence for nature-based strategies to reduce loneliness. While loneliness and despair are reportedly increasing due to social and economic upheaval caused by the COVID-19 pandemic, governments are investing in urban greening. This project aims to help steer greening strategies to reduce loneliness and despair, to enable recoveries from COVID-19 that are more sustainable, equitable and nourishing. This project will: (1) engage with leading scientists within and outside Australia to f ....Generating evidence for nature-based strategies to reduce loneliness. While loneliness and despair are reportedly increasing due to social and economic upheaval caused by the COVID-19 pandemic, governments are investing in urban greening. This project aims to help steer greening strategies to reduce loneliness and despair, to enable recoveries from COVID-19 that are more sustainable, equitable and nourishing. This project will: (1) engage with leading scientists within and outside Australia to formalise my draft conceptual model of pathways linking urban greening with loneliness and despair; (2) test associations and pathways with multiple sources of nationally representative data; (3) supervise a mixed-methods PhD project; and (4) share findings for building up knowledge capacities and guideline development.Read moreRead less
Identifying novel salinity tolerance mechanisms by spatial and temporal analysis of lipids in barley. Agrifood production faces the dual challenges of an increasing world population and the threats of abiotic stresses arising from climate change and the erosion of arable land. Cereals, the major food crops, are poorly adapted to tolerate most abiotic stresses, including salinity. This project applies new technologies investigating spatial and temporal biochemical mechanisms a model cereal, Horde ....Identifying novel salinity tolerance mechanisms by spatial and temporal analysis of lipids in barley. Agrifood production faces the dual challenges of an increasing world population and the threats of abiotic stresses arising from climate change and the erosion of arable land. Cereals, the major food crops, are poorly adapted to tolerate most abiotic stresses, including salinity. This project applies new technologies investigating spatial and temporal biochemical mechanisms a model cereal, Hordeum vulgare (barley), utilises to adapt and tolerate salinity. The aims are to investigate the role of specifically plasma membrane lipids modulating either signalling pathways or membrane fluidity that impacts on adaptation during salinity. The results will provide new leads for the development of cereal germplasm with increased salt tolerance.Read moreRead less
Investigating the molecular mechanisms underlying non-visual photoreception and their implications in the treatment of human neurological disease. The ability of organisms to detect light is fundamental for survival and has been a major driver in evolution. The project will investigate the genetic origins of the various visual and non-visual systems and will explore its implications for the bioengineering of therapeutics for the treatment of neurological disease in humans.