Understanding somatic mutation in plants: new methods, new software, new data. Somatic mutations accumulate as plants grow, affecting everything from short-term ecological interactions to long-term evolutionary dynamics. These mutations have important consequences for plant industry and conservation, but because they are so hard to measure almost nothing is known about them. This project aims to develop new methods and software to detect, analyse, and compare the genome-wide history of somatic m ....Understanding somatic mutation in plants: new methods, new software, new data. Somatic mutations accumulate as plants grow, affecting everything from short-term ecological interactions to long-term evolutionary dynamics. These mutations have important consequences for plant industry and conservation, but because they are so hard to measure almost nothing is known about them. This project aims to develop new methods and software to detect, analyse, and compare the genome-wide history of somatic mutation in individual plants, providing an unprecedented level of detail into an important but understudied source of biological variation. By applying these methods to an iconic experimental population, This project aims to provide the first insights into the genome-wide causes and consequences of somatic mutation in plants.Read moreRead less
Using mathematical modelling to inform HIV/AIDS public health policy. This research will directly inform HIV/AIDS policy officials on the most effective strategies for preventing new cases in HIV in the community. Consequently, there are health benefits for Australia and for the other countries in which the research is being conducted. HIV/AIDS community groups, educators, and other advocacy groups will also be engaged in the research, leading to the development of focussed prevention campaigns ....Using mathematical modelling to inform HIV/AIDS public health policy. This research will directly inform HIV/AIDS policy officials on the most effective strategies for preventing new cases in HIV in the community. Consequently, there are health benefits for Australia and for the other countries in which the research is being conducted. HIV/AIDS community groups, educators, and other advocacy groups will also be engaged in the research, leading to the development of focussed prevention campaigns by these stakeholders to inform the appropriate communities. Reducing the health burdens of HIV/AIDS will also have economic benefits.Read moreRead less
Generating evidence for nature-based strategies to reduce loneliness. While loneliness and despair are reportedly increasing due to social and economic upheaval caused by the COVID-19 pandemic, governments are investing in urban greening. This project aims to help steer greening strategies to reduce loneliness and despair, to enable recoveries from COVID-19 that are more sustainable, equitable and nourishing. This project will: (1) engage with leading scientists within and outside Australia to f ....Generating evidence for nature-based strategies to reduce loneliness. While loneliness and despair are reportedly increasing due to social and economic upheaval caused by the COVID-19 pandemic, governments are investing in urban greening. This project aims to help steer greening strategies to reduce loneliness and despair, to enable recoveries from COVID-19 that are more sustainable, equitable and nourishing. This project will: (1) engage with leading scientists within and outside Australia to formalise my draft conceptual model of pathways linking urban greening with loneliness and despair; (2) test associations and pathways with multiple sources of nationally representative data; (3) supervise a mixed-methods PhD project; and (4) share findings for building up knowledge capacities and guideline development.Read moreRead less
Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk ....Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk of poor mental health, absenteeism, and exit from the workforce. This project will analyse data following people over time to investigate the long-term health and employment consequences of poor psychosocial job quality, and consider the special case of mature age workers. It will identify those individuals at greatest risk, and factors that can buffer against the adverse effects of poor quality work.Read moreRead less
Towards a healthier food supply: achieving policy change and industry action. This research aims to identify mechanisms by which to improve the quality of the Australian food supply. The findings will have the potential to inform government and industry policies on healthier foods with the aim of decreasing chronic disease.
The genetics of resistance to devil facial tumour disease. Tasmanian devils are on the brink of extinction due to a new contagious cancer: Devil Facial Tumour Disease (DFTD). The aim of this project is to determine the genetic nature of DFTD resistance in order to directly contribute to the conservation management of this iconic and ecologically important species. This research will generate fundamental information about genetic diversity in Tasmanian devils and establish the feasibility of bree ....The genetics of resistance to devil facial tumour disease. Tasmanian devils are on the brink of extinction due to a new contagious cancer: Devil Facial Tumour Disease (DFTD). The aim of this project is to determine the genetic nature of DFTD resistance in order to directly contribute to the conservation management of this iconic and ecologically important species. This research will generate fundamental information about genetic diversity in Tasmanian devils and establish the feasibility of breeding resistant animals for release into the wild. Read moreRead less
Reducing the social, economic and health burden associated with obesity-related chronic diseases among socio-economically disadvantaged populations. This project will develop new methods and approaches for reducing obesity-related chronic diseases (OCDs) among socially disadvantaged populations in Australia, using prevention models. These prevention models will improve the evidence base in this field as well as inform public health policy and practice in Australia (and other industrialised count ....Reducing the social, economic and health burden associated with obesity-related chronic diseases among socio-economically disadvantaged populations. This project will develop new methods and approaches for reducing obesity-related chronic diseases (OCDs) among socially disadvantaged populations in Australia, using prevention models. These prevention models will improve the evidence base in this field as well as inform public health policy and practice in Australia (and other industrialised countries).Read moreRead less
Probing the structure of exotic mesons, at the Large Hadron Collider and beyond. Unexpected new particles, outside the bounds of current textbooks, present one of the most interesting puzzles in physics. This project will search for more of these particles at the Large Hadron Collider at CERN, and at new facilities in Japan and Germany that will change particle physics in the coming decade.
Targeting chloroplasts to enhance crop salt tolerance. Yield losses in crop plants due to increasingly saline soils are linked to the effects of salt on chloroplasts. By comparing chloroplast water- and salt-transport mechanisms of closely related salt-loving and salt-sensitive plants, this Fellowships aims to discover how chloroplasts maintain function in saline conditions. Novel biophysics and molecular techniques will be used to characterise transporters in model plants, and proof-of-concept ....Targeting chloroplasts to enhance crop salt tolerance. Yield losses in crop plants due to increasingly saline soils are linked to the effects of salt on chloroplasts. By comparing chloroplast water- and salt-transport mechanisms of closely related salt-loving and salt-sensitive plants, this Fellowships aims to discover how chloroplasts maintain function in saline conditions. Novel biophysics and molecular techniques will be used to characterise transporters in model plants, and proof-of-concept complementation experiments aim to confer salt tolerance on sensitive plants. These fundamental insights are likely to lead to rapid, step-change improvements in salt tolerance, especially in agriculturally relevant crops, to benefit Australia’s agri-industry and ensure food security in the future.Read moreRead less
Room-temperature quantum microscopy for advanced nanoscale imaging. Original, inspired and most often cross-disciplinary efforts are the only way to solve some of nature's most obscure mysteries. Successful development of high-resolution quantum microscopy will lead to a range of benefits for the community and the nation; from graduate student training in cutting edge technology, building links between academic, industry and government groups to providing new insights and approaches into diseas ....Room-temperature quantum microscopy for advanced nanoscale imaging. Original, inspired and most often cross-disciplinary efforts are the only way to solve some of nature's most obscure mysteries. Successful development of high-resolution quantum microscopy will lead to a range of benefits for the community and the nation; from graduate student training in cutting edge technology, building links between academic, industry and government groups to providing new insights and approaches into disease identification and therapy. This project aims to demonstrate a world-first in imaging sensitivity, and success will directly enhance Australia's global reputation as a leader in innovation and collaboration. Read moreRead less