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Understanding The Link Between Mitochondrial Biogenesis And Disease
Funder
National Health and Medical Research Council
Funding Amount
$421,055.00
Summary
As the predominate energy producers of our cells, mitochondria are implicated in a variety of diseases. To function properly, these dynamic organelles rely on protein components that regulate their structure and distribution throughout the cell. My work aims to expand our knowledge of the way these components control mitochondrial shape and trafficking. By understanding the correlation between mitochondrial morphology and function, we will gain insight into related diseases.
Improving The Understanding And Management Of Important Human Bacterial Infections
Funder
National Health and Medical Research Council
Funding Amount
$204,196.00
Summary
This project will focus on two important bacteria, Staphylococcus aureus (Golden Staph), and Enterococcus faecium, both causes of serious infections in hospital and community patients in Australia. Using new technologies, including whole genome sequencing, this project will lead to significant advances in understanding how these bacteria evolve, spread and cause disease. This will lead to new strategies for prevention and management of infections caused by these important bacteria.
Molecular Dissection Of Proteins That Regulate The Invasion Of Toxoplasma Gondii Into Human Cells
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
Toxoplasma gondii is an obligate intracellular parasite responsible for congenital birth defects and disease of immuno-compromised individuals. I propose to identify and characterize molecules essential for T. gondii invasion into human cells. These represent novel targets for therapeutic intervention for disease caused by this important organism.
Functional Genomics-new Technologies For Gene Discovery And Personalised Medicine
Funder
National Health and Medical Research Council
Funding Amount
$452,122.00
Summary
Disorders of the brain, which affect people of all ages, are one of the largest health, economic and social burdens in the developed world. These conditions are chronic, debilitating and have limited symptomatic treatments available. In general, very little is known about the causes of many brain disorders. This project aims to identify the genes and mechanisms that underlie these diseases to enable the development of diagnostic and treatment programs to help reduce the incidence and severity of ....Disorders of the brain, which affect people of all ages, are one of the largest health, economic and social burdens in the developed world. These conditions are chronic, debilitating and have limited symptomatic treatments available. In general, very little is known about the causes of many brain disorders. This project aims to identify the genes and mechanisms that underlie these diseases to enable the development of diagnostic and treatment programs to help reduce the incidence and severity of disease.Read moreRead less
Understanding Adolescent Neurodevelopment: Relevance To Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$447,928.00
Summary
Schizophrenia first appears clinically during late adolescence. This project seeks to understand the molecular changes that occur during adolescent brain development that may underlie the behavioural abnormalities found in schizophrenia. We will focus on Brain derived neurotrophic factor (BDNF), a gene which when reduced is associated with schizophrenia. By examining the role of this gene during adolescent brain development, we will better understand how disruptions to this gene may lead to schi ....Schizophrenia first appears clinically during late adolescence. This project seeks to understand the molecular changes that occur during adolescent brain development that may underlie the behavioural abnormalities found in schizophrenia. We will focus on Brain derived neurotrophic factor (BDNF), a gene which when reduced is associated with schizophrenia. By examining the role of this gene during adolescent brain development, we will better understand how disruptions to this gene may lead to schizophrenia-like behaviours in adulthood.Read moreRead less
Nerve cell survival is dependent on both growth-promoting factors and factors released by neurotransmission, which can promote recovery in neurodegenerative conditions by overriding cell death pathways. The molecule responsible for activating death pathways in the nervous system is called p75. This project will investigate how p75 results in cell death, how synaptic signals can prevent the activation of the p75 death pathway and whether blocking p75 function can limit neurodegeneration.
Molecular Epidemiology Of Cancers Of The Pancreas And Skin.
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
Pancreatic cancer is the 4th most common cause of cancer death in Australia. The causes of this disease are largely unknown. I am conducting research designed to understand genetic and environmental causes of pancreatic cancer. Skin cancer occurs more frequently than any other cancer in Australia. Sunlight is the most common cause but it is also possible that human papilloma viruses may play a role. If high risk types of this virus can be identified, new preventive strategies may be developed.