Defining the antiviral effects of Wolbachia in Aedes aegypti mosquitoes. Mosquitoes that carry a bacterium called Wolbachia do not transmit human pathogenic viruses. These mosquitoes are being developed as a biocontrol tool to prevent mosquito-borne diseases. This project aims to define the molecular basis for virus inhibition by Wolbachia. Using unique biological tools including mosquitoes carrying different strains of Wolbachia that do or do not inhibit dengue virus, the project will define ho ....Defining the antiviral effects of Wolbachia in Aedes aegypti mosquitoes. Mosquitoes that carry a bacterium called Wolbachia do not transmit human pathogenic viruses. These mosquitoes are being developed as a biocontrol tool to prevent mosquito-borne diseases. This project aims to define the molecular basis for virus inhibition by Wolbachia. Using unique biological tools including mosquitoes carrying different strains of Wolbachia that do or do not inhibit dengue virus, the project will define how Wolbachia modifies its host to create an antiviral state. The findings will provide insight into how viral pathogens can be suppressed in insect hosts. This may guide future viral disease intervention strategies for diverse areas afflicted by insect-borne viral disease, including human health and agriculture.Read moreRead less
Ascorbate and glutathione integrate the control of grapevine development. This project aims to make a step-change in understanding how the growth of woody perennial crops is regulated. The study of herbaceous annual plants has established that the antioxidants, ascorbate and glutathione, are important in regulating every step of plant development. However, this cannot readily translate to perennial life cycles. This project will develop novel genetic tools in grapevine that enable functional stu ....Ascorbate and glutathione integrate the control of grapevine development. This project aims to make a step-change in understanding how the growth of woody perennial crops is regulated. The study of herbaceous annual plants has established that the antioxidants, ascorbate and glutathione, are important in regulating every step of plant development. However, this cannot readily translate to perennial life cycles. This project will develop novel genetic tools in grapevine that enable functional studies of these antioxidants in a perennial plant for the first time. It will investigate how ascorbate and glutathione regulate the development of grapevine, and how these functions integrate with hormone and energy metabolism. The outcomes will advance our ability to manage perennial crops in current and future climates.Read moreRead less
The Australian endemic grass tribe Neurachninae: a new paradigm to investigate the evolution of C4 photosynthesis. Two biochemical pathways, known as C3 and C4, account for the photosynthesis of most plants, and C4 plants evolved from C3 ancestors. This project will identify anatomical, biochemical and genetic changes that led to the evolution of C4 plants, aiding development of plant varieties with increased yield and ability to tolerate climate change effects.
Exploiting natural variation to discover tools to increase crop plant yield. This project aims to identify the specific biochemical and underlying molecular modifications that contributed to the evolution of the C4 pathway by studying C3, C4 and C3-C4 intermediate Flaveria species. Most land plants use C3 or C4 photosynthesis to assimilate CO2. Plants using the C4 pathway evolved from C3 ancestors in multiple plant lineages, and show higher rates of photosynthesis and conversion of solar radiati ....Exploiting natural variation to discover tools to increase crop plant yield. This project aims to identify the specific biochemical and underlying molecular modifications that contributed to the evolution of the C4 pathway by studying C3, C4 and C3-C4 intermediate Flaveria species. Most land plants use C3 or C4 photosynthesis to assimilate CO2. Plants using the C4 pathway evolved from C3 ancestors in multiple plant lineages, and show higher rates of photosynthesis and conversion of solar radiation to biomass in arid, high-light and saline environments, which are expanding due to global climate change. The outcomes of this project could define what is required to engineer plant varieties with increased yield and the ability to withstand effects of climate shift, and contribute to our understanding of convergent evolutionary processes.Read moreRead less