Exploring Neurological Complications In Animal Models Of Metabolic Disease
Funder
National Health and Medical Research Council
Funding Amount
$337,432.00
Summary
Diabetes causes ongoing damage to the central and peripheral nervous systems. Our research aims to understand the mechanisms of nervous system damage in diabetes by investigating changes in nervous system function overtime in animal models of pre-diabetes, type 2 diabetes and type 1 diabetes. This study specifically aims to utilize indices that can be correlated with measures obtainable in human studies and thereby achieve results with strong clinical relevance and potential for translation.
Effects Of Increased Endolymph Volume On Cochlear And Vestibular Function And Morphology Of Inner Ear Tissues
Funder
National Health and Medical Research Council
Funding Amount
$313,391.00
Summary
Our recent research suggests that the vertigo attacks associated with enlarged fluid volumes in the inner ear, in diseases such as Ménière's Disease, maybe triggered when the fluid pressure forces open tissue valves located in the fluid-ducts connecting the hearing and balance organs. This project aims to identify the functional role of these valves, and to develop an animal model of abrupt changes in vestibular activity due to hydrops, to allow future treatments to be developed.