Pathogenesis Of Vascular Shock And Platelet Dysfunction In Sepsis: The Role Of Calcium Desensitization, Statins And Cortisol.
Funder
National Health and Medical Research Council
Funding Amount
$89,778.00
Summary
Severe infections are characterised by a profound drop in blood pressure, which starve vital organs of oxygen and nutrients, this �septic shock� can lead to organ failure and death. We aim to identify dysfunction of the molecular signals in blood vessels, which leads to the failure of these vessels to maintain adequate blood pressure. Understanding the mechanisms regulating blood pressure during septic shock will enable us to develop therapies to support the circulation and reduce the significan ....Severe infections are characterised by a profound drop in blood pressure, which starve vital organs of oxygen and nutrients, this �septic shock� can lead to organ failure and death. We aim to identify dysfunction of the molecular signals in blood vessels, which leads to the failure of these vessels to maintain adequate blood pressure. Understanding the mechanisms regulating blood pressure during septic shock will enable us to develop therapies to support the circulation and reduce the significant death toll from life threatening sepsis.Read moreRead less