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Cognition-oriented Treatments For Older Adults On The Spectrum From Cognitive Health To Dementia: Improving Methodologies And Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$716,620.00
Summary
Older adults, with and without memory problems, frequently seek ‘brain stimulating’ activities to reduce their dementia risk. Many such activities are available, but the evidence behind them is not clear and more research is needed to improve our understanding of these treatments. The proposed research programme aims to support older adults interested in these types of activities in their efforts to remain cognitively healthy and functionally independent irrespective of age and clinical status
An Investigation Into The Neural Substrates Of Cognitive Deficits In Mild Cognitive Impairment, And The Mechanisms Of Action Of A Novel Treatment
Funder
National Health and Medical Research Council
Funding Amount
$574,644.00
Summary
Furthering our understanding of the brain mechanisms that underlie the deficits in memory, executive function, and language that occur with Mild Cognitive Impairment is vital for conceptualising the underlying disease processes, and for the development of targeted treatments. Hence, this project will conduct a comprehensive assessment of the brain’s electrical and metabolic responses during specialised cognitive tasks, whilst simultaneously investigating a possible treatment.
Optimising Exercise Prescription For Brain Health In Older Adults At Risk Of Dementia
Funder
National Health and Medical Research Council
Funding Amount
$594,123.00
Summary
To reduce dementia burdens in the community, cost effective and targeted early regenerative strategies are critical. Engaging in frequent aerobic exercise is one strategy that can delay the onset and slow the progression of dementia. However, prescription is limited by an incomplete understanding of how exercise positively influences brain health. Here I will investigate the influence of current exercise levels, intensity and exercise environment on brain health in adults at risk of dementia.
Cross-comparison, Validation And Performance Of Computerised Neuropsychological Assessment Devices In The Evaluation Of Mild Cognitive Impairment And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$700,482.00
Summary
With an ageing population and associated increase in dementia there will be increased demand for neuropsychological assessment, with insufficient trained personnel and resources to meet this demand. Computerised tests offer excellent opportunities for large scale implementation of cognitive screening and monitoring of older adults. This is the first study to systematically evaluate and compare several popular computerised neuropsychological assessment devices in elders with and without dementia.
Vascular Contributions To Dementia: Prevention In Those At High-risk
Funder
National Health and Medical Research Council
Funding Amount
$718,105.00
Summary
10,000 older adults undergo surgeries on their heart every year. These adults are at high risk for dementia, as the factors that bring them to cardiovascular surgery are the same as those that associate with dementia: hypertension, type II diabetes, etc. This population is in fact not only at increased risk of dementia due to vascular ill-health, but also because of undergoing the surgery itself. This project aims to prevent dementia in this vulnerable group.
Novel Assessment And Intervention For Dementia: An Inter-disciplinary Translational Approach
Funder
National Health and Medical Research Council
Funding Amount
$720,021.00
Summary
This program of research focuses on i) a highly novel internationally competitive program of work focusing on the neural network correlates of sleep in dementia, sleep as a risk factor and the efficacy of sleep-wake interventions in reducing cognitive decline; ii) Innovative technologies for widespread screening of preclinical dementia and early intervention and iii) clinical trials focused on the testing of a of novel, highly translatable dementia risk reduction interventions.
This Fellowship will develop novel diagnostic techniques in those patients who are at risk of developing Dementia and Parkinson’s Disease. Participants will also be encouraged to enrol in a brain donation program allowing detailed information for future correlations between symptoms and brain changes. This work will lead to the creation of a diagnostic matrix (At Risk Index) that will provide clinicians and researchers with tools to inform better diagnosis, prognosis and therapy.
More than half of the people living with Alzheimer’s disease experience visual impairments. These impairments may appear before memory problems begin to surface. This research investigates how those at risk of dementia explore the world visually, and how this changes over time. The findings will inform the design of dementia-friendly environments and answer the question whether the assessment of eye movement adds to the diagnosis and prognosis of cognitive impairments.
Cognitive Interventions For Older Adults At-risk Of Dementia And With Early-stage Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$544,348.00
Summary
My postdoctoral research program focuses on secondary prevention for cognitive decline and early intervention for mild-stage dementia, by developing and evaluating cognitive interventions e.g. Cognitive Training, psychoeducation, adjunctive therapies and e-health. I am perfectly positioned for this research, with an established track record in aging, ideal research environment, excellent supervision/collaborative opportunities, and unique background of both research and clinical training.
Moving Behavioural Neuroscience & Neuroeconomics Into Dementia Prevention: Spatial Tracking And Economic Decision-making As New Sensitive Measures Of Daily Function
Funder
National Health and Medical Research Council
Funding Amount
$595,588.00
Summary
This project will aim to develop new measures for clinical trials by learning the relationship between older people's movements around the house, ability to make decisions about their health and finance and their cognitive performance. These instruments may aid future trials of drugs and other interventions for preventing dementia by indicating how basic behavioural patterns respond to interventions.