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MicroRNA Expression Profiling Of Eutopic Endometrium In Women With Versus Without Endometriosis
Funder
National Health and Medical Research Council
Funding Amount
$224,211.00
Summary
Endometriosis is a medical condition where endometrium grows outside the womb. About 10% of women have this condition that can cause abdominal pain, painful periods and difficulty conceiving a child. Now endometriosis can only be diagnosed by surgical procedure. We believe that the presence of endometriosis causes particular small molecules called microRNAs to be present in the lining of the womb or in the blood only in women with endometriosis, and we could develop a test for endometriosis with ....Endometriosis is a medical condition where endometrium grows outside the womb. About 10% of women have this condition that can cause abdominal pain, painful periods and difficulty conceiving a child. Now endometriosis can only be diagnosed by surgical procedure. We believe that the presence of endometriosis causes particular small molecules called microRNAs to be present in the lining of the womb or in the blood only in women with endometriosis, and we could develop a test for endometriosis without resorting to surgery.Read moreRead less
Modulation Of MicroRNA Activity In The Testis: A New Paradigm For Male Fertility?
Funder
National Health and Medical Research Council
Funding Amount
$419,170.00
Summary
Sperm production in the testis is driven by the reproductive hormones, follicle-stimulating hormone (FSH) and testosterone. In this grant, we will investigate how a new class of molecules, called microRNAs, act to transmit the signals from FSH and testosterone to the cellular machinery of the testis, particularly at junctions between cells. This information has the potential to impact on our understanding of the causes of male infertility.
Male-female Sperm Signalling - A Novel Pathway For Peri-conceptual Health?
Funder
National Health and Medical Research Council
Funding Amount
$674,920.00
Summary
This project will investigate a new biological process in reproduction, whereby sperm delivered to the cervix at coitus transmit signalling molecules called microRNAs that influence the female immune response, to increase the chances of conception and pregnancy. We will define the molecular details of this signalling pathway in mouse models, and then determine whether human sperm have a comparable function in ‘priming’ the female body to conceive.